A study of drug utilization pattern and pharmacoeconomic of antidiabetic drugs in patients attending a teaching hospital

Shanthi M.

doi:10.18203/2319-2003.ijbcp20181189

Authors

Shanthi M. Department of Pharmacology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20181189

Keywords:

Drug utilization, Diabetes mellitus, Irrational, Monotherapy, Pharmacoeconomic, Prescription

Abstract

Background: Drug utilization research establishes the current trend in the use of antidiabetic drugs including the new drug and to identify irrational prescription.

Methods: A cross-sectional study was conducted for a period of one year (between August 2013 to August 2014) at outpatient department of Medicine, Sree Mookambika Institute of Medical Sciences, Kulasekharam, Kanyakumari District, Tamil Nadu.

Results: A total of 169 prescriptions were evaluated during the study period. Diabetes mellitus was predominant among the female population in this region. Demographic details of the patient included in the study were mean weight 67.56kg, mean height 155cm and average body mass index 27.82kg/m². All the patients were diagnosed and were known case of type 2 diabetes mellitus. Systemic hypertension was the frequently encountered co-morbid conditions associated with this endocrine disorder. Metformin was the drug chosen for managing diabetes as monotherapy and 73% of the patients were on combination of antidiabetic drugs. Glimepiride with metformin was the combination therapy frequently prescribed during the study period. Pharmacoeconomic analysis identified that drugs prescribed by brand name were costlier compared to generic equivalent.

Conclusions: Utilization of antidiabetic drug therapy in this region has shown a changing trend compared to the previous studies. There is a gradual increase in the prescription of metformin and dramatic increase in the use of newer drugs like pioglitazone, voglibose and sitagliptin. Pharmaeconomic analysis revealed that glibenclamide was least expensive while sitagliptin was most expensive in this study.

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References

Powers AC. Diabetes mellitus. In: Lango LD, Fauci AS, Kasper DL, Hauser SL, editors. Harrison’s Principle of Internal Medicine. Vol II. 18th Ed. New Delhi: McGraw Hill;2012:2968-3003.

Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. The control of blood glucose and drug treatment of diabetes mellitus.7th Ed. London: Elsevier. 2007:372-84.

Powers CA, D’Alessio D. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia. In. Laurence LB, John SL, Keith LP editors. Goodman and Gilman’s Pharmacological Basis of Therapeutics 12th Ed. New Delhi:McGraw-Hill;2011:1238-73.

Kaveeshwari SA, Cornwall J. The current state of diabetes mellitus in India. Australas Med J. 2014;7(1):45-8.

Anjana RM, Pradeepa R, Deepa M, Datta M, Sudha V, Unnikrishnan R, et al. Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase 1 result of the Indian council of medical research-India Diabetes (ICMR-INDIAB) study. Diabetol. 2011;54:3022-7.

Shalini S, Ravichandran V, Mohanty BK, Dhanaraj SK, Saraswathi R. Drug utilization studies-An overview. Inter J Pharmaceut Sci Nanotechnol. 2010;31:803-10.

Mandavi, Cruz SD, Sachdev A, Tiwari P. Adverse drug reactions and their risk factors among Indian ambulatory elderly patients. Indian J Med Res. 2012;136:404-10.

Kumar MA, Nizar A, Shailaja K, Ramasamy C. A study on prescribing pattern and potential drug-drug interactions in type 2 diabetes mellitus (inpatients) in a tertiary care teaching hospital. Der Pharmacia Letter. 2011;3(4):13-9.

Akila L, Sandozi T, Devi AKG, Kumar JS, Balasubramanian A, Rani RJ. Drug utilization study of oral anti-diabetic drug at a tertiary care (SRM Medical College) hospital in Chennai. Int J Med Res. 2011;1(3):177-82.

Acharya KG, Shah KN, Solanki ND, Rana DA. Evaluation of antidiabetic prescription, cost and adherence to treatment guidelines: A prospective, cross-sectional study at a tertiary care teaching hospital. J Basic Clinical Pharm. 2013;4(4):82-7.

Shahir AQ, Kauser S, Dharmender G, Ahmad AN. Prescribing patterns of antidiabetic medications in a tertiary care teaching hospital, Bareilly, UP, India. J Pharm Scientific Innovation. 2013;2(1):41-6.

Abdi SAH, Churi S, Kumar YSR. Study of drug utilization pattern of antihyperglycemic agents in a South Indian tertiary care teaching hospital. Indian J Pharmacol. 2012;44(2):210-4.

Sutharson L, Hariharan RS, Vamsadhara C. Drug Utilization study in Diabetology Outpatient setting of a tertiary hospital. Indian J Pharmacol. 2003;35:237-40.