Loop diuretic-induced hyponatremia: a case report

Authors

  • Bhanu Prakash Kolasani Department of Pharmacology, Vinayaka Missions Medical College & Hospital, Keezhakasakudimedu, Kottuchery, Karaikal, Puducherry
  • C. M. Divya Shanthi Department of Pharmacology, Vinayaka Missions Medical College & Hospital, Keezhakasakudimedu, Kottuchery, Karaikal, Puducherry
  • Prasanand Sasidharan Department of Pharmacology, Vinayaka Missions Medical College & Hospital, Keezhakasakudimedu, Kottuchery, Karaikal, Puducherry

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20150889

Keywords:

Diuretics-induced hyponatremia, Dysguesia, Vasopressin receptor antagonist, Hypertonic saline, Furosemide

Abstract

Hyponatremia is the most common encountered electrolyte abnormality where the serum sodium concentration is <136 mEq/L. The most common causes are either the concurrent illnesses or the medications. Diuretics top the list of drugs inducing hyponatremia and this occurs more frequent within 2 weeks of initiating therapy. Though thiazide diuretics are frequently the culprits of inducing hyponatremia, the role by/risk with loop diuretics cannot be ignored. Prompt diagnosis and management of hyponatremia needs a sound knowledge with which permanent neurologic sequelae and morbidity could be prevented. Here, we report a case of hyponatremia induced by loop diuretic and spironolactone combination, where the presenting complaints of the patient were only intractable nausea and altered taste. The patient was successfully managed with hypertonic saline and the vasopressin receptor antagonist, tolvaptan, which belongs to a new class of drugs called aquaretics.

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Published

2016-12-23

How to Cite

Kolasani, B. P., Shanthi, C. M. D., & Sasidharan, P. (2016). Loop diuretic-induced hyponatremia: a case report. International Journal of Basic & Clinical Pharmacology, 4(5), 1031–1033. https://doi.org/10.18203/2319-2003.ijbcp20150889