Comparative prospective randomized open label trial of synbiotic (bifilac) as an add on therapy with standard treatment in patients with aphthous ulcer
Keywords:Analgesics, Aphthous ulcer, Synbiotic, Lozenges
Background: To trial the safety, efficacy and rapidity of response to a lozenges containing synbiotic in patients with minor aphthous ulcer.
Methods: A total of 60 patients were enrolled for the trial after obtaining IEC approval and randomly allocated into two groups. Control “Group A” was administered with conventional treatment i.e., zytee and B complex for 2 weeks and trial “Group B” was administered with Bifilac along with conventional treatment for 2 weeks. The results of this trial were analyzed both subjectively and objectively.
Results: Comparing with control group, where standard treatment was used with analgesics and B-complex, the trial group showed a quick relief of pain and helped in reducing mean size of ulcer.
Conclusions: This trial was done with synbiotic lozenges in minor aphthous ulcers and it proved to be better alternative for them. Moreover, synbiotics have no adverse effects.
Pandey KR, Naik SR, Vakil BV. Probiotic, prebiotic and synbiotic- a review, J Food Sci Technol 2015 Dec;52(12):7577-87.
Koybasi S, Parlak AH, Serin E, Yilmaz F, Serin D. American J Otolaryngol Head Neck Med Surg. 2006;27:229-32.
Perdigón G. Vintiñi E Alvarez S Medina M Medici M, Trial of the possible mechanisms involved in the mucosal immune system activation by lactic acid bacteria. J dairysci. 1999;2;110-4.
Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc. 2003 Feb;134(2):200-7.
Ship JJ. Epidemiologic aspects of recurrent aphthous ulcerations. Oral Surg. 1972;33:400-6.
Eversole LR. Immuno pathogenesis of oral lichen planus and recurrent aphthous stomatitis. Semin Cutan Med Surg. 1997;16:284-94.
Preeti L, Magesh KT, Rajkumar K, Raghavendhar K. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252-6.
De Souza TO, Martins MA, Bussadori SK, Fernandes KP, Tanji EY, Mesquita-Ferrari RA, et al. Clinical evaluation of low-level laser treatment for recurring aphthous stomatitis. Photomed Laser Surg. 2010;28(2):85-8.
University of Dakota, Prebiotic and Probiotic, American diabetic assoc; 2010. Available at: https://und.edu/student-life/dining/_files/docs/fact-sheets/probiotic.pdf, Accessed 9th February 2018.