Knowledge, attitude and practices of general practitioners about use of antiviral drugs in viral infections other than HIV
Keywords:Anti-viral, General practitioners (GPs), Hepatitis, Herpes, Influenza
Background: Antiviral drugs for viral infections other than HIV are effective only for hepatitis, herpes and influenza. It has been observed that general practitioners (GPs) treat viral infections with antibiotics. The use of antibiotics in viral infections is not rational. Hence, authors conducted this study to assess the Knowledge, Attitude and Practices of General Practitioners (GPs) about treatment of viral infections other than HIV.
Methods: It was a descriptive, observational, cross- sectional study among 100 GPs in Southern Pune. A pretested questionnaire was used to assess their knowledge, attitude and practices about treatment of viral infections other than HIV. Prior informed written consent was taken from the GPs who were grouped under MBBS, BHMS and BAMS categories according to their qualifications. Correct answers among these groups were analysed using chi-square test, Spearman’s coefficient test and ANOVA.
Results: The percentages of correct answers in the groups were comparable.56% GPs have poor knowledge of Influenza treatment.30-36% do not treat Herpes genitalis and zoster with antiviral drugs. Authors found that 44%, 30% and 28% of total GPs don’t have proper knowledge, attitude and practice respectively about common viral infections other than HIV and antiviral drugs.
Conclusions: GPs are significantly unaware about rational use of antiviral drugs. They have poor knowledge about management of influenza.
Raymund R, Razonable, MD. Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus. Mayo Clinic Proc. 2011:86(10):1009-26.
Centers for Disease Control and Prevention. Recommended adult immunization schedule, United States; 2016. Available at: www.cdc.gov/vaccines/schedules/downloads/adult/adult-schedule.pdf. Accessed 31 January 2018.
Gosselin V, Généreux M, Gagneur A, Petit G. Effectiveness of rotavirus vaccine in preventing severe gastroenteritis in young children according to socioeconomic status. Hum Vaccin Immunother. 2016;12(10):2572-9.
Mrozek-Budzyn D, Kieltyka A, Majewska R, Augustyniak M. The effectiveness of rotavirus vaccine in preventing acute gastroenteritis during rotavirus seasons among Polish children. Arch Med Sci: AMS. 2016:12(3):614.
Velázquez RF, Linhares AC, Muñoz S, Seron P, Lorca P, DeAntonio R, et al. Efficacy, safety and effectiveness of licensed rotavirus vaccines: a systematic review and meta-analysis for Latin America and the Caribbean. BMC Pediatr. 2017;17(1):14.
Beri SG, Pandit VA, Khade KS, Sarda KD. The Pattern of Drug Use in Acute Fever by General Practitioners (GPs) in Pune City, India. J Clin Diagn Res. 2013;7(3):467.
Antiviral drugs. In: Tripathi KD. Essentials of Medical Pharmacology. 7th Ed. Jaypee Brothers Medical Publishers; 2013:798-815.
Askarian M, Danaei M, Vakili V. Knowledge, attitudes, and practices regarding pandemic H1N1 influenza among medical and dental residents and fellowships in Shiraz, Iran. Int J Prev Med. 2013:4(4):396.
Gaglia Jr MA, Cook RL, Kraemer KL, Rothberg MB. Patient knowledge and attitudes about antiviral medication and vaccination for influenza in an internal medicine clinic. Clin Infect Dis. 2007:45(9):1182-8.
Zachary KC. Treatment of Seasonal Influenza in Adults. Available at: http://www.uptodate.com/contents/treatment-of-seasonal-influenza-in-adults?detectedLanguage=enandsource=search_resultandsearch=influenzaandselectedTitle=1%7E150andprovider=noProvider#H13/ Accessed 31 January 2018.
Harper SA, Bradley JS, Englund JA, File TM, Gravenstein S, Hayden FG, et al. Seasonal influenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2009:1003-32.
Farrukee R, Hurt AC. Antiviral Drugs for the Treatment and Prevention of Influenza. Curr Treat Options Infect Dis. 2017:9(3):318-32.
Stiver G. The treatment of influenza with antiviral drugs. Can Med Assoc J. 2003:168(1):49-57.
Institute of Medicine (US) Committee on Implementation of Antiviral Medication Strategies for an Influenza Pandemic. Antivirals for Pandemic Influenza: Guidance on Developing a Distribution and Dispensing Program. Washington (DC): National Academies Press (US); 2008. Available at: https://www.ncbi.nlm.nih.gov/books/NBK214504/. Accessed 31 January 2018.
WHO. Antiviral drugs for pandemic (H1N1): definitions and use. 2009. Available at: www.who.int/csr/disease/swineflu/frequently_asked_questions/antivirals/definitions_use/en/. Accessed 31 January 2018
Allen UD, Aoki FY, Stiver HG. The use of antiviral drugs for influenza: recommended guidelines for practitioners. Can J Infect Dis Med Microbiol. 2006;17(5):273-84.
Straus SE, Ostrove JM, InchauspÉ G, Felser JM, Freifeld A, Croen KD, et al. Varicella-zoster virus infections: biology, natural history, treatment, and prevention. Ann Intern Med. 1988:108(2):221-37.
Kempf W, Meylan P, Gerber S, Aebi C, Agosti R, Buchner S, et al. Swiss recommendations for the management of varicella zoster virus infections. Swiss Med Wkly. 2007;137(17/18):239.
Stankus SJ, Dlugopolski M, Packer D. Management of herpes zoster (shingles) and postherpetic neuralgia. Am Fam Physician. 2000;61(8):2437-44.
Dworkin RH, Johnson RW, Breuer J, Gnann JW, Levin MJ, Backonja M, et al. Recommendations for the management of herpes zoster. Clin Infect Dis. 2007;44(1):S1-26.
Notification of dengue cases. New Delhi: Ministry of Health and Family Welfare, Govt. of India; 2018. Available at: http://nvbdcp.gov.in/Doc/notification-of-Denuge-Cases-June2016.pdf. Accessed 31 January 2018.
Das S, Sarfraz A, Jaiswal N, Das P. Impediments of reporting dengue cases in India. J Infect Public Health. 2017;10(5):494-8.
Hanvoravongchai P, Coker R. Early reporting of pandemic flu and the challenge of global surveillance: a lesson for Southeast Asia. Southeast Asian J Trop Med Public Health. 2011;42(5):1093.
Michiels B, Van Puyenbroeck K, Verhoeven V, Vermeire E, Coenen S. The value of neuraminidase inhibitors for the prevention and treatment of seasonal influenza: a systematic review of systematic reviews. PloS one. 2013;8(4):e60348.
Ebell MH, Call M, Shinholser J. Effectiveness of oseltamivir in adults: a meta-analysis of published and unpublished clinical trials. J Fam Pract. 2012;30(2):125-33.
Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson M, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Sao Paulo Med J. 2014;132(4):256-7.