A comparative study for evaluation of cognitive function in type-II diabetes mellitus patients and non-diabetics


  • Dulcie Celia A. Department of Pharmacology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India
  • Ezhil Ramya J. Department of Pharmacology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India
  • Sriviruthi B. Department of Pharmacology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India




Cognitive dysfunction, Standardized Mini Mental State Examination (SMMSE), Type-II diabetes mellitus


Background: To evaluate the impact of type-II diabetes mellitus on cognitive function and to assess the factors associated with impaired function.

Methods: This prospective study compared 100 type-II diabetic people attending the diabetic clinic of Tirunelveli Medical College Hospital with another 100 membered control group. The study group was selected randomly between the age group of 45-65 years. A neuro-cognitive assessment was done using Standardized Mini Mental State Examination (SMMSE), which is a simple and reliable screening test. This scale has 12 questions with time limits to assess orientation, memory, calculation, language, attention and construction. Magnitude and severity of cognitive decrement were analysed along with the possible factors affecting it.

Results: Mean age of the study population was 54.6±7.24 years. Cognitive impairment was noted among 62 of cases and 48 of the control group, which means a 14% higher prevalence of cognitive impairment among the type 2 diabetics. The association of development of cognitive impairment and duration of diabetes mellitus was significant statistically (p value = 0.025443; p<0.05). Other demographic variables like gender, education and domicile were also seen to affect the results.

Conclusions: Mild to moderate cognitive impairment was found significantly higher among the type-II diabetics than the non-diabetics. The cognitive impairment was found to be associated with the duration of diabetes. Hence the routine screening of cognition by SMMSE should be done in all type-II diabetic patients.


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How to Cite

A., D. C., J., E. R., & B., S. (2018). A comparative study for evaluation of cognitive function in type-II diabetes mellitus patients and non-diabetics. International Journal of Basic & Clinical Pharmacology, 7(4), 738–743. https://doi.org/10.18203/2319-2003.ijbcp20181179



Original Research Articles