DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20150886

A study of anti-inflammatory activity of the benzofuran compound (3,4-dihydro 4-oxo-benzofuro [3,2-d] pyrimidine-2-propionic acid) in chronic model of inflammation

Lakshminarayana K., Umesh G. Wari, Suresh S. Kendri

Abstract


Background: Benzofuran compounds are shown to have pharmacological properties such as antiarrhythmic, antidepressant, antifungal, and antibacterial activity. Some studies conducted on them have revealed that they are having anti-inflammatory property also. Hence, we carried out this study to know whether the benzofuran compound 3, 4-dihydro 4-oxo-benzofuro (3, 2-d) pyrimidine-2-propionic acid has got anti-inflammatory activity against chronic inflammation.

Methods: Wistar albino rats were treated with benzofuran compound under study and phenylbutazone in the dose of 100 mg\kg, orally with 2% gum acacia as suspending agent and the effects were observed in chronic experimental model of inflammation namely, cotton pellet induced granuloma model.

Results: In the present study, it was shown that the benzofuran compound under study has got significant anti-inflammatory activity against the chronic model of inflammation.

Conclusion: Our experiment shows that the benzofuran compound under study has got significant anti-inflammatory activity and may, as well become an additional anti-inflammatory drug if further studies are conducted in this direction involving human beings.


Keywords


Benzofurans, Phenylbutazone, Chronic inflammation, Cotton pellets, Granuloma

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References


Mitchell RN, Cotran RS. In: Robbins Basic Pathology. 7th Edition. Philadelphia: Elsevier-Health Publications; 2002: 33.

Bourgery G, Dostert P, Lacour A, Langlois M, Pourrias B, Tisne-Versailles J. Synthesis and antiarrhythmic activity of new benzofuran derivatives. J Med Chem. 1981;24(2):159 67.

Malik WU, Mahesh VK, Raishgani M. Synthesis and biological evaluation of some benzofuran derivatives. Indian J Chem. 1971;9:655.

Shazia NA, Philip CS, Daniel RH. Synthesis of cicerofuran an antifungal benzofuran and some related analogues. Tetrahedron. 2006;62:4214-26.

Kirilmis C, Ahmedzade M, Servi S, Koca M, Kizirgil A, Kazaz C. Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 2. The synthesis and antimicrobial activity of some novel 1-(1-benzofuran-2-yl)-2-mesitylethanone derivatives. Eur J Med Chem. 2008;43(2):300-8.

Sangeetha M, Soni B. In vitro Antiinflammatory studies of 3-(11-benzofuran-2-acyl)-5-aryl isoxozole. Int J Res Pharm Biomed Sci. 2011;2(3):1200-5.

Balasaheb JM, Agasimundin YS. Microwave assisted synthesis of benzofuran analogues of fenamates as NSAIDS. J Child Chem Soc. 2009;54(1):77-9.

Wagner W, Khanna P. In: Katzungs Basic and Clinical Pharmacology. 9th Edition. New York: McGraw Hill; 2001: 586.

Tripathi KD. In: Essentials of Medical Pharmacology. 7th Edition. New Delhi: Brothers Medical Publishers; 2013: 193.

Chakrabarti JK, Eggleton RJ, Gallagher PT, Harvey J, Hicks TA, Kitchen EA, et al. 5-Acyl-3-substituted-benzofuran-2(3H)-ones as potential antiinflammatory agents. J Med Chem. 1987;30(9):1663-8.

Warner Lambert. Pyrimidine fused bicyclic metalloproteinase inhibitors. WO2004014916A1; 2014.

Whelan CJ. Metalloprotease inhibitors as anti-inflammatory agents: an evolving target? Curr Opin Investig Drugs. 2004;5(5):511-6.