A study of anti-inflammatory activity of the benzofuran compound (3,4-dihydro 4-oxo-benzofuro [3,2-d] pyrimidine-2-propionic acid) in chronic model of inflammation

Lakshminarayana K.; Umesh G. Wari; Suresh S. Kendri

doi:10.18203/2319-2003.ijbcp20150886

Authors

Lakshminarayana K. Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Ballari, Karnataka
Umesh G. Wari Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Ballari, Karnataka
Suresh S. Kendri Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Ballari, Karnataka

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20150886

Keywords:

Benzofurans, Phenylbutazone, Chronic inflammation, Cotton pellets, Granuloma

Abstract

Background: Benzofuran compounds are shown to have pharmacological properties such as antiarrhythmic, antidepressant, antifungal, and antibacterial activity. Some studies conducted on them have revealed that they are having anti-inflammatory property also. Hence, we carried out this study to know whether the benzofuran compound 3, 4-dihydro 4-oxo-benzofuro (3, 2-d) pyrimidine-2-propionic acid has got anti-inflammatory activity against chronic inflammation.

Methods: Wistar albino rats were treated with benzofuran compound under study and phenylbutazone in the dose of 100 mg\kg, orally with 2% gum acacia as suspending agent and the effects were observed in chronic experimental model of inflammation namely, cotton pellet induced granuloma model.

Results: In the present study, it was shown that the benzofuran compound under study has got significant anti-inflammatory activity against the chronic model of inflammation.

Conclusion: Our experiment shows that the benzofuran compound under study has got significant anti-inflammatory activity and may, as well become an additional anti-inflammatory drug if further studies are conducted in this direction involving human beings.

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