Evaluation of an anti-diuretic activity of fluvoxamine in albino rats

Nagma Firdose, R. N. Suresha, Mohammed Sibgatullah, Sabreen Bashir, R. Poornima, Divya Reddy


Background: Diabetes insipidus is a disease characterized by high amounts of urine excretion. Antidiuretic drugs are used to treat this condition. Hence, our study intends to evaluate the anti-diuretic effect of fluvoxamine, a selective serotonin reuptake inhibitors in albino rats.

Methods: Albino rats were divided into three groups of six animals each. The control group was fed with distilled water 10 ml/kg body weight, standard group received 4 units of vasopressin and test group received fluvoxamine 18 mg/kg body weight. On the day of experiment, diuresis was induced in all the groups by giving frusemide in a dose of 20 mg/kg body weight after loading with saline at 25 ml/kg body weight. The animals were confined in diuretic cage for a period of 5 hrs and urine output was noted. Urine was analyzed for electrolyte concentration (Na+, K+, Cl−).

Results: There was significant reduction in urine output in the test group of animals when compared to the control group. Electrolyte concentration revealed relatively concentrated urine when compared to the control group.

Conclusions: Fluvoxamine has a significant anti-diuretic action in the albino rats.


Anti-diuretic, Fluvoxamine, Albino rats, Diuretic cage

Full Text:



Jackson KE, Robert Reilly F. Vasopressin and other agents affecting renal conservation of water. In: Brunton LL, Bruce CA, Bjom Knollman C, editors. Goodman and Gillman’s The Pharmacological Basis of Therapeutics. 12th Edition. China: McGraw Hill; 2011: 710.

Verbalis JG. Diabetes insipidus. Rev Endocr Metab Disord. 2003;4(2):177-85.

Grantham JJ, Burg MB. Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules. Am J Physiol. 1966;211(1):255-9.

Christensen O, Sørensen HA, Almdal TP. Adverse effects of selective serotonin uptake inhibitors. Hyponatremia caused by Schwartz-Bartter syndrome. Ugeskr Laeger. 1996;158(48):6920-2.

Pérgola PE, Sved AF, Voogt JL, Alper RH. Effect of serotonin on vasopressin release: a comparison to corticosterone, prolactin and renin. Neuroendocrinology. 1993;57(3):550-8.

Moyses ZP, Nakandakari FK, Magaldi AJ. Fluoxetine effect on kidney water reabsorption. Nephrol Dial Transplant. 2008;23(4):1173-8.

Tripathi KD, editor. Anti depressant and anti anxiety drugs. Essentials of Medical Pharmacology. 6th Edition. New Delhi: Jaypee Brothers; 2008: 446.

Menezes C, Gupta K, Satyanarayana D, Kamath VJ. Evaluation of diuretic activity of Ficus glomerata in experimental animal model. World J Pharm Pharm Sci. 2013;2(1):253-8.