Cyproheptadine adverse drug interaction with anti-epileptic drugs

Authors

  • Ankit Bhardwaj Department of Pharmacology, SIMS, Hapur, Uttar Pradesh, India
  • Anand Shukla Department of Pharmacology, SIMS, Hapur, Uttar Pradesh, India
  • Sunita Singh Department of Pharmacology, SIMS, Hapur, Uttar Pradesh, India
  • Anil Kem Department of Pharmacology, SIMS, Hapur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20180677

Keywords:

Antiepileptic drugs and H1 and 5- HT1/2 receptor antagonist, Cyproheptadine and seizure, H1 and 5- HT1/2 receptor antagonists and seizure

Abstract

Cyproheptadine is a H1 and 5- HT1/2 receptor antagonists, impairing the anticonvulsant activity of antiepileptic drugs and reduces threshold, increases severity of seizures, when administered chronically. Anuj a 13 years old male from Delhi, known case of SSPE stage-III with epilepsy, on oral anti-epileptic drug has seizure induction followed the use of oral cyproheptadine. Stopping cyproheptadine, patient didn’t sustain any further seizures.

References

Singh D, Goel R. Proconvulsant potential of cyproheptadine in experimental animal models. Fundam Clin Pharmacology. 2010 Aug;24(4):451-5.

Ferenc R, Czuczwar SJ. Histamine and the convulsive threshold or effectiveness of antiepileptic drugs. Przegl Lek. 2008;65(11):803-6.

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Published

2018-02-22

How to Cite

Bhardwaj, A., Shukla, A., Singh, S., & Kem, A. (2018). Cyproheptadine adverse drug interaction with anti-epileptic drugs. International Journal of Basic & Clinical Pharmacology, 7(3), 577–578. https://doi.org/10.18203/2319-2003.ijbcp20180677

Issue

Vol. 7 No. 3 (2018): March 2018

Section

Case Reports