DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20180677

Cyproheptadine adverse drug interaction with anti-epileptic drugs

Ankit Bhardwaj, Anand Shukla, Sunita Singh, Anil Kem

Abstract


Cyproheptadine is a H1 and 5- HT1/2 receptor antagonists, impairing the anticonvulsant activity of antiepileptic drugs and reduces threshold, increases severity of seizures, when administered chronically. Anuj a 13 years old male from Delhi, known case of SSPE stage-III with epilepsy, on oral anti-epileptic drug has seizure induction followed the use of oral cyproheptadine. Stopping cyproheptadine, patient didn’t sustain any further seizures.


Keywords


Antiepileptic drugs and H1 and 5- HT1/2 receptor antagonist, Cyproheptadine and seizure, H1 and 5- HT1/2 receptor antagonists and seizure

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References


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Ferenc R, Czuczwar SJ. Histamine and the convulsive threshold or effectiveness of antiepileptic drugs. Przegl Lek. 2008;65(11):803-6.