DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20180667

Antihyperlipidemic activity of Chloroxylon swietenia in triton WR1339 induced hyperlipidemia

B. H. M. R. K. Guptha, S. L. D. V. Ramana Murty Kadali, Vijay Kumar M., Revanasiddappa B. C.

Abstract


Background: Medicinal herbs are beneficial and effective either in the management and prevention of several metabolic disorders, associated with hyperlipidemia, hypertension and insulin resistance which increases the cardio-metabolic risk and demands for the life time therapy. Current allopathic medicines are expensive and reported with several adverse effects and hence, finding of a suitable herbal medicine for hyperlipidemic disorders is very important.

Methods: Thirty albino rats weighing 200-230g were randomly divided into 5 groups were rendered hyperlipidemia with a single dose of triton WR 1339. Normal control, positive control, standard, aqueous and ethanolic extract groups were treated with tween-80, tween-80, atorvastatin, aqueous and ethanolic extracts of Chloroxylon swietenia respectively for seven days. At the end of the study, blood was collected for estimation of the lipid profile.

Results: Both the aqueous and ethanolic extract groups significantly reduced the TG and VLDL levels.

Conclusions: The extracts exhibited remarkable activity on one or either parameter of the lipid profile. It could be due to the presence of alkaloids, steroids, flavonoids, coumarins and phenols in the extracts.


Keywords


Chloroxylon swietenia, Hyperlipidemia, Triton WR 1339

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