Published: 2016-12-23

Knowledge, attitude, and practice of healthcare professionals about adverse drug reaction in major tertiary care teaching hospital in Punjab

Mandeep Kaur, Sourabh Kosey, Raj Kumar


Background: Adverse drug reaction (ADR) has a severe morbidity and mortality associated with it. The safe use of medicines is a critical issue for all healthcare professionals, including physicians, pharmacists, and nurses as well as the public. The main objective of this study was to evaluate the knowledge, attitude, and practice (KAP) of healthcare professionals about ADRs in a tertiary care teaching hospital.

Methods: A cross-sectional survey was carried out among the health care professionals in India using a pre-tested questionnaire with 30 questions (18 questions on knowledge, 6 on attitude, 5 on practice, and 1 on training about reporting of ADR). The study was conducted, over a period of 6 months.

Results: The questionnaire was distributed to the respondents (n=200). The response rate of 85% was recorded. Among these, only 82 questionnaires were filled in pre-test and 88 questionnaires were filled in post-test after improving awareness through pamphlets. Of the total completed questionnaire (88), 34.88% were filled by physicians, 8.53% by pharmacists, 27.9% by nurses, and 31.3% by medical and paramedical interns.

Conclusions: The health care professionals have little KAP toward ADR reporting. Healthcare professionals with higher experience such as (>10 years experience) have better KAP. With additional training on pharmacovigilance, the Indian healthcare professionals working in different sectors can become part of ADR reporting system.


Adverse drug reaction, Pharmacovigilance, Knowledge, Attitude, Practice

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Sivadasan S, Yuong YN, Woan CN, Siew CA, Nazeri AA, Ravichandran V, et al. Knowledge and perception towards pharmacovigilance and adverse drug reaction reporting among medicine and pharmacy students. World J Pharm Pharm Sci. 2014;3(3):1652-76.

Ahmad A, Patel I, Balkrishnan R, Mohanta GP, Manna PK. An evaluation of knowledge, attitude and practice of Indian pharmacists towards adverse drug reaction reporting: a pilot study. Perspect Clin Res. 2013;4(4):204-10.

Vora MB, Paliwal NP, Doshi VG, Barvaliya MJ, Tripathi CB. Knowledge of adverse drug reactions and pharmacovigilance activity among the undergraduate medical students of Gujarat. Int J Pharm Sci Res. 2012;2(5):1511-5.

Tandon VR, Khajuria V, Mahajan A, Gillani Z, Mahajan V, Chandail V. Fatal adverse drug reactions: experience of adverse drug reactions in a tertiary care teaching hospital of North India - a case series. Indian J Crit Care Med. 2014;18(5):315-9.

Karelia Bharti N, Piparava Kiran G. Knowledge, attitude and practice of pharmacovigilance among private healthcare professionals of Rajkot City. Int J Basic Clin Pharmacol. 2013;3:50-3.

Abdel-Latif MM, Abdel-Wahab BAL. Knowledge and awareness of adverse drug reaction and pharmacovigilance practices among health care professionals in AL-Madinah AL-Munawwarah, Kingdom of Saudi Arabia. Saudi Pharm J. 2014;3(5):1-8.

Rama P, Rodrigues PA, Georgy A. Pharmaovigilance: perspectives and future challenges in Indian scenario. Asian J Pharm Clin Res. 2011;4(4):1-4.

Upadhyaya HB, Vora MB, Nagar JG, Patel PB. Knowledge, attitude and practices toward pharmacovigilance and adverse drug reactions in postgraduate students of tertiary care Hospital in Gujarat. J Adv Pharm Technol Res. 2015;6(1):29 34.

Rehan HS, Sah RK, Chopra D. Comparison of knowledge, attitude and practices of resident doctors and nurses on adverse drug reaction monitoring and reporting in a tertiary care hospital. Indian J Pharmacol. 2012;44(6):699-703.

Fadare JO, Enwere OO, Afolabi AO, Chedi BA, Musa A. Knowledge, attitude and practice of adverse drug reaction reporting among healthcare worker in a tertiary center in northern Nigeria. Med J Armed Force India. 2011;10:235 42.

Jose J, Jimmy B, Al-Ghailani AS, Al Majali MA. A cross sectional pilot study on assessing the knowledge, attitude and behavior of community pharmacists to adverse drug reaction related aspects in the Sultanate of Oman. Saudi Pharm J. 2014;22(2):163-9.

Gawde SR, Shetty YC, Pawar DB. Knowledge, attitude and practices toward ayurvedic medicine use among allopathic resident doctors: a cross-sectional study at a tertiary care hospital in India. Perspect Clin Res. 2015;4(2):1-6.

Khalili H, Mohebbi N, Hendoiee N, Keshtkar AA, Dashti-Khavidak S. Improvement of knowledge, attitude and perception of healthcare workers about ADR, a pre and post-clinical pharmacists’ interventional study. BMJ Open. 2014;2(2):1-6.

Desai CK, Iyer G, Panchal J, Shah S, Dikshit RK. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting among prescribers at a tertiary care hospital. Perspect Clin Res. 2011;2(4):129-36.

Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279(15):1200-5.

World Health Organization: safety of Medicines - A Guide to Detecting and Reporting Adverse Drug Reactions. WHO/EDM/QSM/2002.2. Geneva, Switzerland: World Health Organization; 2002.