A study to evaluate compliance in patients of diabetes mellitus in a North-Indian tertiary care hospital


  • Prashant Shukla Department of Pharmacology, Government Medical College, Patiala, Punjab, India
  • Shikha Palta Department of Pharmacology, Government Medical College, Patiala, Punjab, India
  • Anita Gupta Department of Pharmacology, Government Medical College, Patiala, Punjab, India
  • Vijay K. Sehgal Department of Pharmacology, Government Medical College, Patiala, Punjab, India




Diabetes mellitus, Medication adherence, Medication compliance, Morisky Medication Adherence Scale (MMAS) -8 item questionnaire


Background: The objective of the study was to determine level of adherence and recognize various causative factors which can affect the compliance in the diabetic patients.

Methods: This was an observational study. The study was conducted by enrolling patients of the outpatient department of Medicine of Rajindra Hospital, Government Medical College, Patiala, Punjab. To assess adherence, a questionnaire was administered to the patients - Morisky Medication Adherence Scale (MMAS) -8 item questionnaire. The various factors affecting compliance was determined by a researcher made questionnaire.

Results: Out of a total of 100 subjects, age range extended from 18 years to 80 years. The mean age was 57.52±12.33years. 51% of patients were females and 49% was males. Analysis of MMAS- 8 item scores of patients showed that 52% of patients had low adherence, 29% had medium while 19% had high adherence to the treatment. Only 30% patients were compliant i.e. with HbA1C value of 7 or less while 70% patients were non-compliant i.e. with HbA1C value of more than 7.

Conclusions: Compliance to medical treatment is influenced by a myriad of factors. In order to promote compliance, it is necessary to increase awareness about the disease, possible complications and treatment guidelines among patients as well as their family members. 


Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al. Harrison's Principles of Internal Medicine. 17th Ed. New York, USA: Mc Graw Hill. Diabetes Mellitus; 2008;Chapter 338:2275-2304.

Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3(11):e442. Available at: http://www.who.int/mediacentre/factsheets/fs312/en/

World Health Day 2016. Diabetes. World Health Organization. Available at: http://www.searo.who.int/india/mediacentre/events/2016/en/

Joshi S, Parikh R. India - Diabetes capital of the world: Now heading towards hypertension. J Assoc Phy India. 2007;55:323-4.

Chatterjee S, Davies MJ. Current management of diabetes mellitus and future directions in care. Postgraduate Medical Journal. 2015;91:612-21.

McNabb WL. Adherence in Diabetes: Can We Define It and Can We Measure It? Diabetes Care 1997 Feb;20(2):215-8.

Jimmy B, Jose J. Patient Medication Adherence: Measures in Daily Practice. Oman Medical Journal. 2011;26(3):155-9.

Morisky DE, Green LW, Levine DM. Concurrent and Predictive Validity of a Self‐Reported Measure of Medication Adherence. Medical Care. 1986;24(1):67‐74.

Pati S, Schellevis FG. Prevalence and pattern of co morbidity among type2 diabetics attending urban primary healthcare centers at Bhubaneswar (India). PLoS ONE 2017;12(8):e0181661. Available at: https://doi.org/10.1371/journal.pone.0181661

Iglay K, Hannachi H, Howie PJ, Xu J, Li X, Engel SS, et al. Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus. Current Med Res Opinion. 2016;32(7):1243-52.

Shah VN, Kamdar PK, Shah N. Assessing the knowledge, attitudes and practice of type 2 diabetes among patients of Saurashtra region, Gujarat. International Journal of Diabetes in Developing Countries. 2009;29(3):118-22.

Al-Rasheedi AA. Glycemic Control among Patients with Type 2 Diabetes Mellitus in Countries of Arabic Gulf. International Journal of Health Sciences. 2015;9(3):345-50.

Tizazu A, Hussien Y, Mebratu S, Agalu A. Substance use among diabetic patients in Dessie Referral Hospital, Northeast Ethiopia. Research Desk. 2012;1(1):40-6.

Sontakke S, Jadhav M, Pimpalkhute S, Jaiswal K and Bajait C. Evaluation of Adherence to Therapy In Patients of Type 2 Diabetes Mellitus. Journal of Young Pharmacists. 2015;7(4s):462-9.

Sharma T, Kalra J, Dhasmana DC, Base H. Poor adherence to treatment: a major challenge in diabetes. JIACM. 2014 Jan;15(1):26-9.

Sajith M, Pankaj M, Pawar A, Modi A, Sumariya R. Medication adherence to antidiabetic therapy in patients with type 2 Diabetes Mellitus. Int J Pharm Pharmceu Sci. 2014;6(2):564-70.

Jemal A, Abdela J, Sisay M. Adherence to Oral Antidiabetic Medications among Type 2 Diabetic (T2DM) Patients in Chronic Ambulatory Wards of Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia. J Diabetes Metab. 2017;8(1):1000721.




How to Cite

Shukla, P., Palta, S., Gupta, A., & Sehgal, V. K. (2018). A study to evaluate compliance in patients of diabetes mellitus in a North-Indian tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 7(3), 480–485. https://doi.org/10.18203/2319-2003.ijbcp20180661



Original Research Articles