Effect of fluoxetine and paroxetine on intestinal motility


  • Ayesha Afzal Department of Pharmacology, Wah Medical College (UHS), Wah, Cantt, Pakistan
  • Mahjabeen Sharif Department of Pharmacology, Army Medical College, Rawalpindi, Pakistan
  • Ammara Khan Department of Pharmacology, Gujrat Medical College, Gujrat, Pakistan
  • Bushra Tayyaba Khan Department of Pharmacology, Army Medical College, Rawalpindi, Pakistan
  • Iffat Ara Department of Pharmacology, Wah Medical College (UHS), Wah, Cantt, Pakistan




Diarrhea, Fluoxetine, Gastrointestinal tract, Paroxetine, Power lab, Serotonin


Background: Serotonin (5-HT) is a biogenic amine that functions as a neurotransmitter of sensorimotor functions in the digestive tract. Te role of 5-HT agents in the modulation of lower gastrointestinal function. Selective serotonin reuptake inhibitors (SSRIs) are of potential benefit in functional gastrointestinal diseases although formal evidence is lacking. Apart from central effects, they may have peripheral. The present study was carried out to find out the possible effects of fluoxetine and paroxetine on gastrointestinal smooth muscles of rabbit as they cause severe nausea and vomiting initially.

Methods: Experimental study design. Power lab (USA) for recording the contractions of ileal smooth muscle of rabbit in response to serotonin, fluoxetine and paroxetine.

Results: The percent responses with serotonin, fluoxetine and paroxetine were 100, 10.53, and 4.75 percent respectively.

Conclusions: SSRIs (fluoxetine and paroxetine) were unable to enhance the serotonergic transmission in vitro inturn decreases the qualitative response.


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How to Cite

Afzal, A., Sharif, M., Khan, A., Khan, B. T., & Ara, I. (2018). Effect of fluoxetine and paroxetine on intestinal motility. International Journal of Basic & Clinical Pharmacology, 7(3), 429–432. https://doi.org/10.18203/2319-2003.ijbcp20180654



Original Research Articles