Anti-ulcer effect of rhizome of Curcuma longa Linn, by the method of pyloric ligation


  • Jayan Pariyani Savaringal Department of Pharmacology, Govt. Medical College, Thrissur, Kerala, India
  • Sanalkumar K. B. Department of Pharmacology, Govt. Medical College, Thrissur, Kerala, India



Curcuma longa, Pyloric ligation, Ranitidine, Shay ulceration


Background: Substantial part of the world population has been known for a long time to suffer from peptic ulcer disease. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its anti-ulcer properties.

Methods: The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxhlet extraction with 50% ethanol. Albino rats of Wistar strain (120-200 grams) obtained from the animal house of medical college Thiruvananthapuram were used. Ranitidine was collected from Kerala Sate Drugs and Pharmaceutical LTD Alapuzha. Antiulcer study in rats were done using the method of pyloric ligation.

Results: Antiulcer study in rats using the method of pyloric ligation, extract of Curcuma longa in 1000mg/Kg dose levels exhibited significant protection against shay ulceration. The results were comparable to that of standard drug Ranitidine.

Conclusions: The present study with extract of Curcuma longa revealed that it has significant anti-ulcer activity.


Ammon HPT, Wahl MA. Pharmacology of Curcuma longa. Planta Medica. 1991;57:1-7.

Rafathullah S, Tariq M, Al-Yahya MA, Mossa JS, Ageel AM. Evaluation of Curcuma longa for gastric and duodenal ant-ulcer activity in rats. J Ethanopharmacol. 1990;29(1):25-34.

Mukherjee B, Zaidi SH, Singh GB. J of Sci Industr Res. 1961;20:25-8.

Xiao X, Zhao Y, Yuan H, Xia W, Zhao J, Wang X. Study on the effect of Rhizoma Curcuma longa on gastrin receptor. Zhong Yao Cai. 2002;25(3):184-5.

Mahady GB, Pendland SL, Yun G, Li ZZ. Inhibitory action of turmeric and curcumin on the growth of H.pylori, a group - Ì carcinogen. Anticancer Res. 2002;22(6):4179-81.

Abdul-Aziz KK. Comparative evaluation of the anti-ulcer activity of curcumin and omeprazole during the acute phase of gastric ulcer. Food Nut Sci. 2011;2:628-40.

Shay H, Komarov SA, Fels SS, Meranzie D, Gruenstein M, Siplet H. Gastroenterology. 1945; 5:43.

Badilla B, Miranda T, Mora G, Vargus K. The gastrointestinal activity of an aqueous extract of the dry wood of Quassia amara. Revi Biol Tropical. 1998; 46(2):203-10.

Burtis CA, Ashwood ER. Tietz Text Book of Clinical chemistry. 3rd Ed. London. W. B. Saunders Company. 1999;1288-9.

Sairam K, Rao CV, Goel RK. Effect of Centella asiatica Linn. on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J Exp Bio. 2001;39(2):137-42.

Vogel GH, Vogel WH. Drug Discovery and Evaluation: pharmacological assays.1st Ed. Berlin. Springer; 1997:487.

Brodie DA. Experimental gastric ulcers. Gastroenterology. 1968;55:125-34.

Marks IN, Young GO, Tigler-Wybrandi NA, Bridger S, Newton KA. Acid-secretory response and parietal cell sensitivity in patients with duodenal ulcer before and after treatment with sucralfate or ranitidine. The American journal of medicine. 1989;86(6):145-7.

Johnston DA, Marks IN, Young GO. Acid secretory responses and parietal cell sensitivity following duodenal ulcer healing with omeprazole, sucralfate, and Maalox. Am J Med. 1991;91:915-45.

Marks IN, Jonston DA, Young GO. Acid secretory changes and early relapse following duodenal ulcer healing. Am J Med. 1991;91:955-1015.

Jones DB, Howden CW, Burget DW. Alteration of H2 receptor sensitivity in duodenal ulcer patients after maintenance treatment with H2 receptor antagonists. Gut. 1988;29:890-3.

Dedieu-Chaufour CA, Hertz F, Caussade F, Cloarec A. Pharmacological profile of UP 5145-52, an original antiulcer and antisecretory agent. J of Pha and Exp The. 1991;259(1):190-7.

Miller TA. Mechanism of stress related mucosal damage. Am j Med. 1987;83:14.

Senay CE, Levine RJ. Synergism between cold and restraint for rapid production of stress ulcer in rats. Proc Soc Experimentation Biol Med. 1967;124:1221.

Haubrich WS, Schaffner F, Berk JE, Bockus HL. Bockus gastroenterology. 7th Ed. WB Saunders Co. 1995;714-732.

Singh RK, Nath G, Goel RK, Bhattacharya SK. Pharmacological actions of Abies pindrow Royale leaf. Indian J Exp Biol. 1998;36:187-91.

Yu ZF, Kong LD, Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol. 2002;83(1-2):161-5.

Gujral ML, Chowdhury NK, Saxena PN. Wound healing property of curcuma powder Indian Med Assoc. 1953;22:273.

Domschke W, Domschke S, Hagel J. Gastric epithelial cell turn over mucous production and healing of gastric ulcers with carbenoxolone. Gut. 1977;18:817-20.

Bonvicin F, Maltarello MC, Versura P. Correlative scanning electron microscopy in the study of human gastric mucosa. Scanning Electron Microsc. 1986;2:687-702.

Younan F, Pearson J, Allen A. Changes in the structure of the mucous gel on the mucosal surface of the stomach in association with peptic ulcer diseases. Gastroenterology. 1982;82:827-31.

Goel RK, Sairam K. Anti ulcer drugs from indigenous sources with emphasis on Musa sapientum, Tamrabhasma, Asparagus racemosus, and Zingiber officinale. Indian J Pharmacol. 2002;34:100-10.

Hiruma-Lima CA, Gracioso JD, Toma W, de Paula AC, De Almeida AB, Brasil DD, et al. Evaluation of the gastroprotective activity of cordatin, a diterpene isolated from Aparisthmium cordatum (Euphorbiaceae). Biol Pharm Bull. 2000;23(12):1465-9.

Antonio MA, Souza Brito AR. Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). J Ethnopharmacol. 1998;61(3):215-28.

Goel RK, Gupta S, Shankar R, Sanyal AK. Anti-ulcerogenic effect of Musa sapientum Var. paradisiaca (Banana powder) and its effects on mucosal resistance. J Ethnopharmacol. l996;18:33.

Goel RK, Bhattacharya SK. Gastroduodenal mucosal defence and mucosal protective agents. Indian J Exp Bio. 1991;29:701.

Mukherjee B, Zaidi SH, Singh GB. Journal of Sci Industr Res. 1961;20:25-8.

Pizorrno JE, Murray MT. Textbook of natural medicine, 2nd Ed. London: Churchill Livingstone; 1999;689-693.

Ananthanarayanan R, Jayarampaniker CK. Textbook of Microbiology. 6th Ed. Orient Longman Pvt Ltd; 2000:376-377.

Toda S, Miyase T, Arich H. Natural antioxidants: antioxidative compounds isolated from rhizome of Curcuma longa Linn. Chem Pharmacol Bull. 1985;33:1725-8.

Srivastava R. Inhibition of neutrophil response by curcumin. Agents Actions. 1989;28:298-303.

Srihari T, Basu N, Siddiqui HH. Action of extract of Curcuma longa on the stimulant effect produced on guinea pig ileum by histamine, serotonine and nicotine. Indian J Med Res. 1982;75:574-8.

Qvist G, Dormandy J, Brown C. The experimental production of gastric ulcers by induced muscle spasam. Br J Surg. 1974;61:259-63.

Chattopadhyay I, Biswas K, Bandyopadhyay U. Turmeric and curcumin: Biological actions and medicinal applications. current science-Bangalore. 2004;87(1):44-53.

Ajamal A. Effect of turmeric in peptic ulcer and Helicobacter pylori. Plant Sciences Research. 2011;3(3):25-8.




How to Cite

Savaringal, J. P., & B., S. K. (2017). Anti-ulcer effect of rhizome of Curcuma longa Linn, by the method of pyloric ligation. International Journal of Basic & Clinical Pharmacology, 7(1), 20–26.



Original Research Articles