DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20175485

To evaluate the anti-inflammatory activity of ramipril in albino rats

Siddamma Amoghimath, Suresha R. N., Jayanthi M. K.

Abstract


Background: Angiotensin II (Ang II) is a product of Renin angiotensin aldosterone system (RAAS). Angiotensin‑II regulates vascular tone, stimulates the release of pro‑inflammatory cytokines, activates nuclear factor‑kappa B (NF‑κB), increases oxidant stress and functions as an inflammatory molecule. Ramipril an ACE inhibitor act by inhibiting angiotensin converting enzyme, decreases angiotensinogen II activity. Hence the present was to evaluate the anti-inflammatory activity of Ramipril.

Methods: Eighteen Wistar albino rats weighing around 150-200gms of either sex were randomly selected from central animal facility and divided into three groups. The control group received normal saline 25ml/kg, standard group received Indomethacin 10mg/kg and test group received Ramipril (0.9mg/kg) orally for six days. The animals were subjected to carrageenan induced paw oedema and cotton pellet induced granuloma model.

Results: Ramipril significantly decreased the mean paw oedema in carrageenan induced paw oedema when compared to control and in cotton pellet induced granuloma Ramipril decreased the mean granuloma weight when compared to control.

Conclusions: Ramipril showed anti-inflammatory activity when given for 6 consecutive days per orally in albino rats in carrageenan induced paw oedema and cotton pellet induced granuloma model.


Keywords


Angiotensin II, Carrageenan, Cotton pellet, NF-κβ, ROS

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