Published: 2016-12-23

Drug utilization study on antidiabetic medications at SIMS-Shimoga a tertiary care hospital

H. Vedavathi, Shreenivas P. Revankar


Background: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. DM is a leading cause of blindness, end stage renal disease, and nontraumatic lower extremity amputations. The objective of the study was to evaluate the drug utilization pattern of antidiabetic medications at a tertiary care hospital.

Methods: Demographic details of the patient were noted. Evaluation of the written prescription was carried out according to the requirements in case record form followed by computerization of data and analysis.

Results: DM was almost equal in male (51%) and females (49%), the risk of DM was high after 40 years of age. Out of all the case records and prescriptions reviewed it was found that 23% had Type 1 DM, and 77% had Type 2 DM. In 46.35% cases, there was a family history of DM while in 47.44% cases it was absent, 6% were unaware. The average number of drugs per prescription was 3.26±0.24 and antidiabetic drugs at 1.72±0.28. Insulin alone was prescribed in 25.54% cases. Single antidiabetic agents as lone drugs were seen in 39.05%; combined oral antidiabetic drugs accounted for 25.54% cases. The combination of insulin and oral antidiabetic agents were prescribed in 9.85% cases.

Conclusion: Metformin was the oral hypoglycemic agents, which was the most frequent prescribed as was insulin and its analogs. These drugs being essential in the treatment of diabetic patients should be made available to patients all the time.


Diabetes mellitus, Drug utilization, Prescription, Analysis, Insulin, Antidiabetic

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Powers AC. Diabetes mellitus. In: Kasper DL, Fauci AS, Longo DL, Ameson JL, Loscalzo J, Hauser SL, et al., editors. Harrison’s Principles of Internal Medicine. 17th Edition. New York: The McGraw-Hill Companies, Inc.; 2008.

WHO. Global Status Report on Non-Communicable Diseases. Geneva: World Health Organization; 2010.

William D. Current Clinical Medicine. USA: Elsevier, Saunders; 2009: 349-63.

Park K. Parks Text Book of Preventive and Social Medicine. 23rd Edition. India: Bhanoth Publishers; 2015: 392-6.

Brenner GM, Stevens CW. Pharmacology. 3rd Edition. Cheltenham: Elsevier Publishers; 2012: 138-9.

Tripathi KD. Essentials of Medical Pharmacology. 7th Edition. New Delhi: Jaypee Publications; 2013: 579-93.

Tissot E, Henon T, Cornette C, Jacquet M. Incomplete prescription: a potential medication error. Presse Med. 1999;28(12):625-8.

Vengurlekar S, Shukla P, Patidar P, Bafna R, Jain S. Prescribing pattern of antidiabetic drugs in Indore city hospital. Indian J Pharm Sci. 2008;70(5):637-40.

Adibe MO, Aguwa CN, Ukwe CV, Okonta JM, Udeogaranya PO. Outpatient utilization of antidiabetic drugs in the southeastern Nigeria. Int J Drug Dev Res. 2009;1(1):27-36.

Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharm Ther. 2010;35(3):267-77.

Upadhyaya DK, Palaian S, Shankar R, Mishra P. Knowledge, attitude and practice about diabetes among diabetes patients in western Nepal. RMJ. 2008;33(1):8-11.

Rajeshwari S, Adhikari P, Prabha MR, Pai MR. Drug utilization study in geriatric type 2 diabetic patients. J Clin Diagn Res. 2007;1:440-3.

Abdi SA, Churi S, Kumar YS. Study of drug utilization pattern of antihyperglycemic agents in a South Indian tertiary care teaching hospital. Indian J Pharmacol. 2012;44(2):210-4.

Hermann LS. Biguanides and sulfonylureas as combination therapy in NIDDM. Diabetes Care. 1990;13 Suppl 3:37-41.

Buse JB. Overview of current therapeutic options in type 2 diabetes. Rationale for combining oral agents with insulin therapy. Diabetes Care. 1999;22 Suppl 3:C65-70.

Eldor R, Raz I. American Diabetes Association indications for statins in diabetes: is there evidence? Diabetes Care. 2009;32 Suppl 2:S384-91.

Colwell JA; American Diabetes Association. Aspirin therapy in diabetes. Diabetes Care. 2004;27 Suppl 1:S72-3.

Chow CC, Tsang LW, Sorensen JP, Cockram CS. Comparison of insulin with or without continuation of oral hypoglycemic agents in the treatment of secondary failure in NIDDM patients. Diabetes Care. 1995;18(3):307-14.