DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20175207

Evaluation of anti-inflammatory effect of beetroot extract in animal models

Anjan Adhikari, Aioshi Saha, Rania Indu, Tapas Kumar Sur, Anup Kumar Das

Abstract


Background: Inflammation is complex biological response of body tissues to foreign particles or pathogens. However, adverse effects of anti-inflammatory drugs, necessitate the search for a novel compound from herbal origin. Beta vulgaris rubra or red beetroot, a vegetable plant, is known to possess various beneficial effects. Present study aimed to evaluate the anti inflammatory effect of beet roots in animal models.

Methods: Carrageenan-induced and Complete Freund’s adjuvant-induced rat paw edema model were used to assess the acute and chronic anti- inflammatory potential of the Beetroot as compared to standard drug, Diclofenac Sodium.

Results: Oral administration of Beetroot extract showed carrageenan-induced rat paw edema inhibition by 26.9%, 34.6% and 50% for beetroot 100mg/Kg, 200mg/Kg and 400mg/Kg, respectively, at the end of four hours. In vivo results noted that percentage inhibition of paw volume and ankle diameter of the Complete Freund’s adjuvant-induced rats were significantly higher for the groups consuming 100 and 200mg/Kg Beetroot extracts. Paw volume of the rats in these two groups reduced by 35% and 30% respectively as compared to the control.

Conclusions: Thus, beetroot was found to possess anti-inflammatory property in animals. Further investigations are essential to validate the bioactive components responsible for this property.


Keywords


Anti-inflammation, Beta vulgaris, Carrageenan, Complete Freund’s adjuvant

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