Evaluation of anti-inflammatory effect of beetroot extract in animal models

Anjan Adhikari; Aioshi Saha; Rania Indu; Tapas Kumar Sur; Anup Kumar Das

doi:10.18203/2319-2003.ijbcp20175207

Authors

Anjan Adhikari Department of Pharmacology, R. G. Kar Medical College, 1, Khudiram Bose Sarani, Kolkata 700004, West Bengal, India
Aioshi Saha Department of Biotechnology, Institute of Genetic Engineering, 30, Thakurhat Road, Badu, Kolkata 700128, West Bengal, India
Rania Indu Department of Pharmacology, R. G. Kar Medical College, 1, Khudiram Bose Sarani, Kolkata 700004, West Bengal, India
Tapas Kumar Sur Department of Pharmacology, Institute of Post Graduate Medical Education & Research, 244 A.J.C Bose Road, Kolkata 700020, West Bengal, India
Anup Kumar Das Department of Pharmacology, R. G. Kar Medical College, 1, Khudiram Bose Sarani, Kolkata 700004, West Bengal, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20175207

Keywords:

Anti-inflammation, Beta vulgaris, Carrageenan, Complete Freund’s adjuvant

Abstract

Background: Inflammation is complex biological response of body tissues to foreign particles or pathogens. However, adverse effects of anti-inflammatory drugs, necessitate the search for a novel compound from herbal origin. Beta vulgaris rubra or red beetroot, a vegetable plant, is known to possess various beneficial effects. Present study aimed to evaluate the anti inflammatory effect of beet roots in animal models.

Methods: Carrageenan-induced and Complete Freund’s adjuvant-induced rat paw edema model were used to assess the acute and chronic anti- inflammatory potential of the Beetroot as compared to standard drug, Diclofenac Sodium.

Results: Oral administration of Beetroot extract showed carrageenan-induced rat paw edema inhibition by 26.9%, 34.6% and 50% for beetroot 100mg/Kg, 200mg/Kg and 400mg/Kg, respectively, at the end of four hours. In vivo results noted that percentage inhibition of paw volume and ankle diameter of the Complete Freund’s adjuvant-induced rats were significantly higher for the groups consuming 100 and 200mg/Kg Beetroot extracts. Paw volume of the rats in these two groups reduced by 35% and 30% respectively as compared to the control.

Conclusions: Thus, beetroot was found to possess anti-inflammatory property in animals. Further investigations are essential to validate the bioactive components responsible for this property.

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