Elevated liver enzymes after olanzapine use: a case report
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20160130Keywords:
Olanzapine, Liver enzymes, Bipolar maniaAbstract
Olanzapine is a second-generation antipsychotic used in bipolar mania and schizophrenia. We are reporting the case of a young female patient who developed elevated liver enzymes after olanzapine use. Patient's liver enzymes improved after the discontinuation of olanzapine making it a possible cause for reversible hepatotoxicity. We recommend physicians to check liver enzymes regularly if patient is on olanzapine.
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References
Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry. 2005;10(1):79-104.
Manceaux P, Constant E, Zdanowicz N, Jacques D, Reynaert C. Management of marked liver enzyme increase during olanzapine treatment: a case report and review of the literature. Psychiatr Danub. 2011;23(1):S15-17.
Divac N, Prostran M, Jakovcevski I, Cerovac N. Second generation antipsychotics and extrapyramidal adverse effects. BioMed Res Intl. 2014;2014. http://dx.doi.org/10.1155/2014/656370.
Tikka SK, Pratap A, Sinha VK. Dose-dependent Olanzapine-induced myolonus. Toxicol Int. 2014;21(3):335-6.
Sun Z, Wang X. Case report of refractory tardive dystonia induced by olanzapine. B Shanghai Arch Psychiatry. 2014;26(1):51-3.
Basu A, Kundu S, Khurana H. Olanzapine-induced restless leg syndrome: A case report and review of literature. Indian J Pharmacol. 2014;46:450-2.
Kerr TA, Jonnalagadda S, Prakash C, Azar R. Pancreatitis following olanzapine Therapy: A report of three cases. Case Rep Gastroenterol. 2007;1(1):15-20.
Tuglu C, Erdogan E, Abay E. Delirium and extrapyramidal symptoms due to a lithium-olanzapine combination therapy: A case report. J Korean Med Sci. 2005;20(4):691-4.
Olsson R, Zettergren L. Anticonvulsant-induced liver damage. Am J Gastroenterol. 1988;83(5):576-7.
Atasoy N, Erdogan A, Yalug I, Ozturk U, Konuk N, Atik L et al. A review of liver function tests during treatment with atypical antipsychotic drugs: a chart review study. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(6):1255-60.