DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20174657

The effects of aqueous ginger extract on aluminium chloride (AlCl3) induced alteration in lipid profile of male wister rats

Asha P. Dass, Prashanth Chary Ramoji

Abstract


Background: This study was aimed at investigating the effects of aluminium chloride (AlCl3) in altering the serum lipid profiles and ways to reduce its effect using two different doses of ginger extract 500mg/kg and 1000mg/kg body weight in male wister rats.

Methods: The rats were randomly divided into 4 groups consisting of 5 animals in each group. Groups II, III and IV received AlCl3 100mg/kg bodyweight single dose, Groups III and IV receiving an additional daily oral single dose of ginger plant extract through a stomach tube. All animals were fasted before the treatment. All rats were weighed before the start of the experiment and at the end of the experiment. The blood was collected firstly at the beginning of the experiment, then on the 45th day. The collected blood was left to clot then centrifuged at 3500 rpm for 5 min. The serum was separated and stored at - 80°C for later analyses.

Results: This study shows that a single dose of 100mg/kg aluminium chloride causes a rise in total body weight, TC (total cholesterol), LDL (low density lipoproteins) and TG (triglycerides) levels in the rat, and aqueous Zingiber officinal (ginger) extract reduces this rise in TC, LDL and TG levels in the rats.

Conclusions: Ginger was effective in lowering serum cholesterol levels levels in the ginger treated rats to almost normal value. These results indicate that treatment with aqueous extract of ginger may be effective in lowering lipid levels in AlCl3 induced hyperlipidemia in rats.


Keywords


: Aluminium chloride, Hyperlipidemia, Zingiber officinal

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References


Greger JL, Goetz W, Sullivan, D. Aluminum levels in foods cooked and stored in aluminum pans, trays and foil. J. Food Protect. 1985;48 (9):772-7.

Pennington JA, Schoen SA. Estimates of dietary exposure to aluminium, Food Addit Contam. 1995 Jan-Feb;12(1):119-28.

DeVoto E1, Yokel RA. The biological speciation and toxicokinetics of aluminum. Environ Health Perspect. 1994 Nov;102(11):940-51.

Cournot-Witmer G, Zingraff G, Ptachot JJ. Effect of aluminium on bone and cell localization. Kid Int. 1986;29:537-40.

Johnstone T. Aluminum and Alzheimer's disease. CMAJ. 1992 Feb 15;146(4):431-2.

Zachariah TJ, Ginger. In: Parthasarathy VA, Champakam B, Zachariah TG. editors. Chemistry of Spices. CABI. 2008:70-100.

Shinashal RZ, AL-Sultan RK, Abdalmajeed SA. The Effect of Ginger on The Histopatholoical Lesions of Salmonella Typhimurium in Mice Liver in Comparison with Cephalexin. J Kirkuk Univ Sci Stud. 2012;7:14-23.

Ali B, Tanira G, Nemmar A. Some phytochemical,pharmacological and toxicological properties of Ginger (Zingiber officinale Roscoe), a review of recent research.Food chem Toxicol. 2008;46:409-20.

Shen CL, Hong KJ, Kim SW. Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthritic cartilage explants. J Med Food. 2003;6:323-8.

Mascolo N, Jain R, Jain SC, Capasso F. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol. 1989;27:129-40.

Elshater AA, Salman MMA, Moussa MMA. Effect of Ginger extract consumption on levels of blood glucose, lipid profile and kidney functions in alloxan-induced diabetic rats. Egypt Acad J Biol Sci. 2009;2:153-62.

El-Maraghy SA, Gad MZ, Fahim AT, Hamdy MA. Effect of cadmium and aluminum intake on the antioxidant status and lipid peroxidation in rat tissues.

Tanabe M, Chen YD, Saito K, Kano Y. Cholesterol biosynthes inhibitory component from Zingiber officinale Roscoe. Chem Pharm Bull (Tokyo). 1993;41:710-3. [PubMed: 8508473]

Bhandari U, Sharma JN, Zafar R. The protective action of ethanolic ginger extract in cholesterol-fed rabbits. J Ethnopharmacol. 1998;61:167-71. [PubMed: 9683348]

Srinivasan K, Sambaiah K. The effect spices on cholesterol 7 alpha-hydroxylase activity on serum and on hepatic cholesterol levels in rat. Int J Vitam Nutr Res. 1991;61:364-9. [PubMed: 1806542]

Ness GC, Zhao Z, Lopez D. Inhibitor of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. Arch Biochem Biophys. 1991;325:242-8. [PubMed: 8561503]

Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr. 2000;130:1124-231.

Prasad SS, Kumar S, Vajpeyee SK, Bhavsar VH. To Establish the Effect of Ginger-Juice Zingiber Officinale (Zingiberaceae) on Important Parameters of Lipid Profile. Int J Pharma Sci Res. 2012;3:352-6.

Cardia G, Grisorio D, Impedovo G, Lillo A, Regina G. Plasma lipid as a risk factor in peripheral vascular disease. Angiology. 1990;41:19-22. [PubMed: 2305996]

Murcia MA, Egea I, Romojaro F, Parras P, Jiménez AM, Martínez-Tomé M. Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure. J Agric Food Chem. 2004;52:1872-81. [PubMed: 15053523]

Yen GC, Chong Y, Su S. Antioxidant activity and active compounds of rice koji fermented with Aspergillus candidus. Food Chem Toxicol. 2003;83:49-52.

Belinky PA, Aviram M, Fuhrman B, Rosenblat M, Vaya J. The antioxidant effects of isoflavon glibridin on endogenous constituents of LDL during its oxidation. Atherosclerosis. 1998;137:49-61. [PubMed: 9568736]

Liu N, Huo G, Zhang L, Zhang X. Effect of Zingiber officinale roscoe on lipid per oxidation in hyperlipidemia rats. Wei Sheng Yan Jiu. 2003;32:22-3. [PubMed: 12731279]

Akhany SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of i officinale in streptozotocin-induced type 1 diabetic rats. J Pharm Pharmacol. 2004;56:101-5. [PubMed: 14980006]

Platel K, Srinivasan K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung. 2000;1:42-6. [PubMed: 10702999]