DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20173735

A study of hypoglycemic effect of Caesalpinia bonduc extract on alloxan induced diabetic albino rats

Reshma Nadaf

Abstract


Background: The objective of the study was to scientifically investigate the oral hypoglycemic activity of Caesalpinia bonduc on Alloxan induced diabetic albino rats. To compare the hypoglycemic effect of Caesalpinia bonduc with that of the standard drug Glibenclamide used in the treatment of diabetes mellitus.

Methods: Adult healthy albino rats of wister strain of either sex weighing 150-200gms were included in the study. The animals were divided into 4 groups namely control, diabetic control, standard and test groups with 6 animals in each group. Diabetes was chemically induced using alloxan to produce hyperglycemia in rats. Standard drug Glibenclamide suspended in gum acacia was administered for standard group. Test drug Caesalpinia bonduc was administered for test group. Morning around 9 a.m. blood glucose levels were recorded on 1st, 3rd, 7th, 14th, 21st, and 28th days.

Results: The control group of rats showed no variation. The diabetic control rats showed consistent hyperglycemia. Comparing the test drug Caesalpinia bonduc to the standard drug Glibenclamide, the test drug was 1.38 times more efficacious than the standard.

Conclusions: The alcoholic extract of Caesalpinia bonduc (seeds) has shown more anti diabetic activity by lowering the blood glucose levels in diabetic rats significantly. These findings suggest that hypoglycemic potential of the test compound Caesalpinia bonduc is promising and found to be more significant than the standard compound.


Keywords


Caesalpinia bonduc, Diabetes mellitus, Glibenclamide

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References


Park K. Diabetes mellitus. Parks textbook of preventive and social medicine. 24th Edi. Jabalpur: M/S Banarsidas Bhanot Publishers; 2017:411.

Adithan C. pharmacological research in India, 1972-1995. An analysis based on IPS conference. Indian J Pharmacol. 1996;28:125-8.

Suba V, Murugesan T, Arunachalam G, Mandal SC. Anti diabetic potential of Bacleria lupilina extracts in rats. Phytomed. 2004;11:202-5.

Grover JK, Yadav, Vats V. medicinal plants of India with anti diabetic potential. J. Ethnopharmacology. 2002;81:81-100.

Sharma SR, Dwiwedi SK, Swaroop D. Hypoglycemia, anti hyperglycemic activity and hypoglycemic activity of Caesalpinia bonduc seeds and seeds in rats; J Ethnopharmacol; 1997:58(1):39-44.

Doux SP, Woodley SE, Palton NJ, Wilson GL. Mechanism of nitrosourea induced b- cell damage: Alteration in DNA. Diabetes. 1986;35:866-72.

Chakrabarty S, Biswar TK. Antidiabetic activity of Caesalpinia bonduc. J Etnopharmacol. 2005;97(1):81-100.

Grover JK, Yadav S, Vali V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol. 2002;81(1):117-22.

Cohen G, Heikkila RE. Acute effects of Alloxan on metabolism and insulin secretion of beta cells. Journal Biol Exptl, 1974;38:249-51.

Junad A. Diabetogenic action of Streptozotocin. J clin Invest. 1969;126:201-5.

Dey L, Attele AS, Yuan CS. Alternative therapies for type 2 Diabetes. Alternative Medicine Review. 2002;7(1):45-58.

Gujral VK. Oral hypoglycemic agents: where do we stand today?. Medicine Update. 2008;18:441-51.

Tripathi KD. Insulin, Oral Hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology. 7th Ed. New Delhi: Jaypee; 2013:258-281.

Parameshwar S, Srinivasan KK, Mallikarjun C. Oral antidiabetic activity of different extracts of Caesalpinia bonduc seeds kernels. J Pharmaceutical biology. 2002;40(8):590-5.