Antibacterial susceptible pattern of ear, nose and throat in paediatric patient infections

Selvaraj Rajendran, Chakrapani Cheekavolu, Rama Mohan Pathapati, Madhavulu Buchineni


Background: To study the bacterial pathogens of ear, nose and throat (ENT) to determine the frequency and sensitivity pattern of ENT infections in paediatric patients.

Methods: The study was conducted during the period of June 2016 to May 2017 in Kerala Medical College Hospital. A total 225 samples were collected and evaluated for microbiological investigations. Antimicrobial susceptibility profile was determined by modified Kirby Bauer disc diffusion method.

Results: Out of 225 samples, 140 (62.22%) were found positive growth and 85 (37.77%) of samples were found negative culture. The frequency of different organisms isolated was as follows: Pseudomonas 43 (30.71%), Staphylococcus aureus 32 (22.85%), Proteus spp. 18 (12.85%) Klebsiella spp. 17 (12.14%) etc., Antibiotic susceptibility pattern gram positive bacteria were vancomycin (100%) followed by amikacin (97.14%), and in gram negative bacteria; sulbactam/ cefoperazone (97.14%), piperacillin/tazobactam (95.23%) and meropenem (94.28%) were the most effective drugs.

Conclusions: Pseudomonas aeruginosa, Staphylococcus aureus, Proteus spp. and Klebsiella spp. are the leading ENT pathogens in paediatric patients. Most of the isolates showed high resistance to cephalosporins. Showed high effectiveness to sulbactam/ cefoperazone, piperacillin/tazobactam.


Antibiotics, Paediatric ENT infections, Susceptibility

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Resistance to antibiotic and other antimicrobial agents. House of Lords Select Committee on Science and Technology. 7th Report. London,

Krishnaswamy K, Kumar DB, Radhaiah G. A drug survey precepts and practices. Eur J clin pharmacol 1985;29:363-70.

Bhargava KB, Bhargava SK, Shah TM. A Short Textbook of E.N.T. Diseases. Usha publications, India, 2005;7:110.

Healy GB, Teele DW. The Microbiology of chronic middle ear effusions in children. Laryngoscope. 1977;8:1472.

Daly A. Knowledge and attitude about otitis media risk: implication for prevention. J Paediatrics. 1997;100:93-6.

Aroll B. Antibiotics for upper respiratory tract infection. J Resipir Med. 2005;99:250-5.

Pettigrew MM, Janneane FG, Revai K, Patel JA, Chonmaitree T. Microbial interactions during upper respiratory tract infections. Emerg Infect Dis. 2008;14(10):1584-91.

Levinson W. Antimicrobial drugs, mechanism of action. Review of medical Microbiology and Immunology. 10th Ed. New York: Mc Graw Hill; 2008.

Chessbrough, M. District laboratory practice in tropical countries. (part 2). UK: Cambridge University Press; 2000.

Viastarakos PV, Nikolopoulos TP, Maragoudakis P, Tzagaroulakis A, Ferekidis E. Biofilms in ear, nose, and throat infections: how important are they. Laryngoscope. 2007;117(4):668-73.

Khanna V, Chander J, Nagarkar NM, Dass A. Clinicomicrobiologic evaluation of active tubotympanic type chronic suppurative otitis media. J otolaryngol. 2000;29:148-53.

Nandimath MK, Ahuja S. Drug prescribing pattern in upper respiratory tract infection in children aged 1-14 years. IJBS. 2012;3(1):299-308.

Akinjogunla OJ, Eghafona NO, Enabulele IO. Aetiologic agents of acute otitis media; prevalaence, antibiotic suseptibility, β-Lactamase and extended spectrum β- Lactamase production. Journal of Microbiology and Food Sciences. 2011;3(1):333-53.

Tahiri Z, Mustafa A. Pathogenic microbiological flora recovered from ear, nose and throat specimens in regional hospital in Kosovo. Nigerian J of Medicine. 2008;17(3):275-9.

Dechen TC, Pal R, Kar S. Understanding the clinicomicrobiological spectrum of common ear, nose and throat infections in Sikkim, India. J Glob Infect Dis. 2011;3(2):202.

Deb T, Ray D. A study of the bacteriological profile of chronic suppurative otitis media in Agartala. Indian Journal of otolaryngology and Head and Neck Surgery. 2011;64(4):326-9.

Singh AH, Basu R, Venkatesh A. Aerobic bacteriology of chronic suppurative otitis media in Rajahmundry, Andhra, Pradesh, India. Biology and Medicine. 2012;4(2):73-9.

Mirza IA, Ali L, Ali L, Arshad M. Microbiology of chronic suppurative otitis media-Experience at Bahawalpur. Pakistan Armed Forces Medical J. 2008;58(4):372-6.