Effects of vitex agnes castus on hormonal imbalances in Polycystic Ovary Syndrome
Keywords:Hormonal imbalance, Polycystic ovary syndrome, Phytochemical analysis, Vitex agnus castus
Background: The polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. Its incidence is assessed at 6-8% of the female population in the reproductive age. It is caused by an imbalance of the female sex hormones and higher levels of male hormones called androgens.
Methods: In women with PCOS, the ovaries make more androgens than normal. High levels of these hormones affect the development and release of eggs during ovulation. Hence the hormonal imbalance were studied in three groups. In the present study ,8mg of estradiol valerate was used to induce PCOS in female albino rats. The levels of leutinizing hormone, follicle stimulating hormone, testosterone, dehydroepiandrosterone sulphate, Estradiol, Progesterone, and Prolaction were studied.
Results: The phytochemical analysis of vitex agnus castus was carried out and the positive effects of vitex agnus castus on the hormonal irregularities of PCOS were also studied. The present findings indicated that vitex agnus castus was found to be rich in phytochemicals.
Conclusions: The hormonal levels highly reflect the underlying hormonal imbalance in PCOS and the results obtained in the present study also proved that vitex agnus castus is more efficient in reversing the adverse effects of hormonal imbalance of PCOS.
Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova WD. Chaste tree (Vitex agnus castus). Pharmacological and clinical indications, Phytomedicine. 2003;10:348-57.
Gerhard I, Patek A, Monga B, Blank A. Gilling-Smith C, Story H, Rogers V, Franks S. Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol. 1997a;47(1):93-9.
Gulcin I. The antioxidant and radical scavenging activities of black pepper seed. J. Food Sci. Nutr. 2005;56(7):491-9.
Brawer JR, Munoz M, Farookhi R. Development of the polycystic ovarian condition(PCO) in the estradiol valerate-treated rat. Biol. Reprod. 1986;35:647-55.
Brawer JR, Naftolin J, Martin J, Sonnenschein C. Effects if a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat. Endocrinology. 1978;103:501-12.
Baird DT, Corker CS, Davidson DW, Hunter WM, Michie EA, Van Look PF. Pituitary-ovarian relationships in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 1977;45:798-801.
McKenna TJ. Pathogenesis and treatment of polycystic ovary syndrome. N Engl J Med. 1988;318:558-62.
Merz PG, Gorkow C, Schroedter A, Rietborch S, Sieder C, Loew D, et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Exp. Clin. Endocrinol. Diab. 1996;104:447-53.
Gerhard I, Patek A, Monga B, Blank A, Gilling-Smith C, Story H, et al. Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol. 1997a;47(1):93-9.
Hadju A, Hohmann J, Forgo P, Martinek T, Dervarics M, Zupko I, et al. Deterpenoids and flavonoids from the fruits of vitex agnus castus and antioxidant activity of the fruit extracts and their constituents. Phytother. Res. 2007;21(4):391-4.
Welschen R. Amounts of gonadotropins required for normal follicular growth in hypohysecomized adult rats. Act Endocrinol. 1973;72:137-55.
McGuffin M, Hobbs C, Upton R, Goldberg A. Botanical Safety Handbook; CRC Press: Boca Raton; 1997:231.
Amann W. Acne vulgaris and Agnus castus (Agnolyt®). Z. Allgemeinmed. 1975;51:1645-8.
Agbaht K, Yerlikaya H, Demir O, Gullu S. Hyperprolactenemia in polycystic ovary syndrome. Endocrine Abstracts. 2009;20:653.
Yi L, Lilan L, Haibo Z. Levels of lipid perioxides and superoxide dismutase in peritoneal fluid of patients with endometriosis. Journal of Huazhong University of Science and Technology. Medical Sciences. 2001 Jun 1;21(2):166-7.