Assessment of knowledge, attitude and practices among the residents and interns about rational fixed drug combinations in tertiary health care centre in Central India

Authors

  • Pallavi Admane Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Sachin Hiware Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Mohini Mahatme Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Sujata Dudhgaonkar Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Mukunda Bargade Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Swapnil Deshmukh Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20173739

Keywords:

ADR, FDC, NELM

Abstract

Background: Fixed drug combination (FDC) is a combination of two or more active drugs in a single dosage form. Rational fixed drug combination improves patient compliance, enhances the efficacy of combination and minimizes side effects. But unfortunately, many FDCs introduced in Indian market are irrational. Prescription of irrational FDCs increases morbidity, mortality, treatment failure, emergence of resistance and financial loss to community. Since junior doctors like residents and interns are the backbone in patient care in the tertiary care hospital, knowledge of FDC in them has paramount importance.

Methods: A prospective, cross sectional, observational study was carried out to assess the knowledge, attitude and practice about the use of FDC by junior resident doctors and interns. A pre-validated questionnaire was given to two hundred doctors from various departments and data was analyzed. Questions were based on knowledge of National Essential List of Medicine (NELM), rational FDC and criteria of rationality.

Results: Seventy six percent health care professionals had the knowledge of FDC. Only 48% were aware about FDCs mentioned in WHO Essential List of Medicine. Most of them were aware of advantages and disadvantages of FDCs. Common sources of information were medical representatives, textbooks and Current Index Of medical Specialities (CIMS). Fifty eight percent doctors preferred to prescribe FDC, and ninety two percent avoid use of irrational FDCs. Most commonly prescribed rational fixed drug combination was amoxicillin + clavulanic acid. Paracetamol + ibuprofen was the most commonly prescribed irrational FDC.

Conclusions: There is need to improve knowledge of rational fixed drug combination, NELM list.

References

Sreedhar D, Subramanian G, Udupa N. Combination drugs: Are they rational? Curr Sci. 2006;91:406.

Essential drugs: 19th updated WHO Model List; 2015. Available at: http://www.who.int/medicines/publications/essentialmedicines/en/. Accessed 8 May 2015.

Kastury N, Singh S, Ansari KU. An audit of prescription forrational use of fixed dose drug combinations. Indian J Pharmacol. 1999;31:367-9.

Panda J, Tiwari P, Uppal R. Evaluation of rationality of some FDC: focuson antihypertensive drugs. Indian J Pharm Sci. 2006;68(5):649-53.

Raina S. Assessment of knowledge, attitude, and practice in health care delivery. N Am J Med Sci. 2013;5:249-50.

Badran IG. Knowledge, attitude and practice the three pillars of excellence and wisdom: A place in the medical profession. Eastern Mediterranean Health Journal. 1995;1:8-16.

Shewade D, Pradhan S. Auditing of prescriptions in a government teaching hospital and four retail medical stores in Pondicherry. Indian J Pharmacol. 1998;30:408-10.

Petri WA. Penicillins, Cephalosporins, and Other β-lactam Antibiotics. In: Goodman and Gilman’s the pharmacological basis of therapeutics. 12thed. Brunton LL, Lazo JS, Pasrker KL, editors, McGraw Hill; 2011:1477-1503.

Shewade D, Pradhan S. Auditing of prescriptions in a government teaching hospital and four retail medical stores in Pondicherry. Indian J Pharmacol. 1998;30:408-10.

Gulhati CM. Monthly index of medical specialities, India. MIMS India. 2005;25:81-94.

Greenhalgh T. Drug prescription and self medication in India: Anexploratory survey Soc Sci Med. 1987;25:307-18.

Central drugs standard control organization. Drugs banned in India. 2012. Available at: http://cdsco.nic.in/html/drugsbanned. Accessed 12 June 2012.

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Published

2017-08-22

How to Cite

Admane, P., Hiware, S., Mahatme, M., Dudhgaonkar, S., Bargade, M., & Deshmukh, S. (2017). Assessment of knowledge, attitude and practices among the residents and interns about rational fixed drug combinations in tertiary health care centre in Central India. International Journal of Basic & Clinical Pharmacology, 6(9), 2172–2176. https://doi.org/10.18203/2319-2003.ijbcp20173739

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Original Research Articles