Olanzapine-induced black hairy tongue: a rare case


  • Vishal P. Giri Department of Pharmacology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India
  • Debranjan Datta Department of Pharmacology, TMMCRC, Moradabad, Uttar Pradesh, India
  • Parvathi Devi Department of Oral Medicine and Radiology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India




Atypical antipsychotic, Bipolar disorder, Hairy tongue


Olanzapine is second generation antipsychotic drug. It alters affinities for serotonin and dopamine receptors and provides mild sedating and calming effect. It is indicated for the treatment of schizophrenia, acute mania and the prevention of relapse in bipolar disorder. We present a case report of a 65- year- old man with bipolar disorder I, who developed black hairy tongue following treatment with olanzapine and completely recovered after withdrawal of treatment. Awareness about this particular adverse drug reaction will ensure proper management and avoid unnecessary investigations.


The use of the WHO-UMC system for standardized case causality assessment. World Health Organization (WHO)- Uppsala Monitoring Centre. [Last accessed on 2013 Apr 10]. Available at: http://www.who-umc.org/Graphics/24734.pdf .

Naranjo CA, Busto U, Sellars EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-45.

Marder SB, Hurford IM, Kammen DD. Second generation antipsychotics. In: Sadock BT, Sadock VA, Ruitz P, eds. Kaplon and Sadock’s Comprehensive Text Book of psychiatry, 9th Ed. Philadelphia, Lippin William and Wikins; 2009:3121-3125.

Reus V. Mental disorders. In: Kasper DL, Hauser SL, Jameson JL, Fausi AS, Longo DL, Loscaizo J, eds. Harrison’s principles of internal medicine. 19th Ed. USA Mc Graw-Hill; 2015:2720-2721.

Gurvits GE, Tan A. Black hairy tongue syndrome. World J Gastroenterol. 2014;20:10845-50.

Arab JP, Vargas JI, Morales C, Arrese M. Black hairy tongue during interferon therapy for hepatitis C. Annals of hepatology. 2015;14:414-5.

Edelman M, Indyk D, Yeroshalmi F. Black hairy tongue in a new born infant. J Oral Sci Health. 2014;3:1-7.

Theoni P, Evagelia L, Vassiliki S, Athanasios M. Teeth and tongue discoloration after linezolid treatment in children. Pediatric Infect Disease Journal J. 2013;32:1284-85.

Tamam L, Annagur BB. Black hairy tongue associated with olanzapine treatment; a case report. Mount Sinai Journal of Medicine. 2006;73:891-4.

Jhaj R, Gour PR, Asti DP. Black hairy tongue with a fixed dose combination of olanzapine and fluoxetine. Indian J Phramacol. 2016;48:318-20.

Kanodia S, Giri VP, Veerabhadrappa RS, Giri OP, Shankar VN. Black hairy tongue with olanzapine: A rare case report. Indian J Psychiatry. 2017;59:249-50.

Khasawneh FA, Moti DF, Zorek JA. Linezolid-induced black hairy tongue: a case report. J Med Case Resp. 2013;7;46.

James WD, Berjer TG, Elston DM, eds. Andrew’s diseases of the skin clinical dermatology. 11th Ed. Elsevier Inc; 2011:789.




How to Cite

Giri, V. P., Datta, D., & Devi, P. (2017). Olanzapine-induced black hairy tongue: a rare case. International Journal of Basic & Clinical Pharmacology, 6(8), 2091–2093. https://doi.org/10.18203/2319-2003.ijbcp20173302



Case Reports