A study of prescription pattern in the drug therapy of acne vulgaris at a tertiary care hospital in Mangalore, India


  • Pooja M. Department of Pharmacology, BGS Global Institute of Medical Sciences, Bengaluru, Karnataka, India
  • Rajendra Holla Department of Pharmacology, K. S. Hegde Medical Academy, Mangaluru, Karnataka, India
  • Girisha B. S. Department of Dermatology, Justice K. S. Hegde Charitable Hospital, Mangaluru, Karnataka, India
  • Puneeth A. Department of Biochemistry, Sakra World Hospital, Bengaluru, Karnataka, India




Acne Vulgaris, Dermatology, Rational prescription


Background: Acne Vulgaris is the most common skin disorder of the pilosebaceous unit with excess sebum production, follicular epidermal hyperproliferation, inflammation and Propionibacterium acnes activity, affecting about 80% of teenagers and has considerable psychological and social consequences and physical disability. Use of established topical and oral drugs assumes paramount importance in the treatment of acne vulgaris. Therefore, periodic auditing of prescription is necessary to increase therapeutic benefit and decrease adverse effects. Aim and objectives of the study was to evaluate the pattern of prescription and its rationale in the drug therapy of acne vulgaris. To monitor the adverse effects, if any.

Methods: A prospective, hospital based, observational study. Data was collected for a period of 1 year from January 2015 to December 2015 from the outpatient records in the OPD of Dermatology at Justice K.S. Hegde Charitable Hospital, Deralakatte, Mangalore, in a specifically designed proforma.

Results: The prescription data of 346 patients were analyzed of which 45.1% were males with an average age of 21.94±0.3 years. Among the four grades of Acne Vulgaris, Grade II (53.17%) was more prevalent followed by Grade I (26.58%), Grade III (13.87%) and Grade IV (6.35%). The number of drugs prescribed for topical use was 514 of which the most commonly prescribed drugs were Benzoyl Peroxide (19.46%), a combination of Tretinoin and Clindamycin (17.12%), Tretinoin alone (12.45%), Clindamycin alone (10.51%) etc. The number of drugs prescribed for systemic use was 98 consisting of Doxycycline (55.1%), Azithromycin (34.7%), Isotretinoin (6.12%) and Erythromycin (4.08%).

Conclusions: There was rationality in most of the prescriptions giving no scope for polypharmacy.


The skin microbiome. Nat Rev Microbiol. 2013;9(4):244-53.

Verhoeven EWM, Kraaimaat FW, Weel C Van, Duller P, Hoogen HJM Van Den, Schers HJ, et al. Skin diseases in family medicine. Prevalence and health care use. Ann Fam Med. 2008;6(4):349-54.

Barankin B, DeKoven J. Psychosocial effect of common skin diseases. Can Fam Physician. 2002;48:712-6.

Purdy S, Langston J, Tait L. Presentation and management of acne in primary care: a retrospective cohort study. Br J Gen Pract. 2003;53(492):525-9.

Tabasum H, Ahmad T, Anjum F, Rehman H. The Historic Panorama of Acne Vulgaris. 2013;2(1):99-104.

Titus S, Hodge J. Diagnosis and treatment of acne. Postgrad Med. 1955;17:205-9.

Ramli R, Malik AS, Hani AFM, Jamil A. Acne analysis, grading and computational assessment methods: An overview. Ski Res Technol. 2012;18(1):1-14.

Thappa D, Adityan B, Kumari R. Scoring systems in acne vulgaris. Indian J Dermatol Venereol Leprol. 2009;75(3):323.

Hp L, Acad A, Wj C, Sc B, Jb L, Wj C, et al. Acne Global Severity Scale. 2002.

Tan J. Current Measures for the Evaluation of Acne Severity. Expert Reviews Dermatology. 2008;3(5):595-603.

Purdy S, Deberker D. Acne vulgaris Search date June 2007 Skin disorders Acne vulgaris. Clin Evid (Online). 2008;05(1714):1-34.

Strauss JS, Krowchuk DP, Leyden JJ, Lucky AW, Shalita AR, Siegfried EC, et al. Guidelines of care for acne vulgaris management. J Am Acad Dermatol. 2007;56(4):651-63.

Desalegn AA. Assessment of drug use pattern using WHO prescribing indicators at Hawassa University teaching and referral hospital, south Ethiopia: a cross-sectional study. BMC Health Serv Res. 2013;13(1):1-6.

Tunger O, Karakaya Y, Cetin CB, Dinc G, Borand H. Rational antibiotic use. J Infect Dev Ctries. 2009;3(2):88-93.

Shankar PR, Upadhyay DK, Subish P, Dubey AK, Mishra P. Prescribing patterns among paediatric inpatients in a teaching hospital in western Nepal. Singapore Med J. 2006;47(4):261-5.

Potharaju HR, Kabra SG. Prescription audit of outpatient attendees of secondary level government hospitals in Maharashtra. Indian J Pharmacol. 2011 Apr;43(2):150-6.

Santosh K, Shaktibala D, Mirza AB, Anil KM, Mohammed A, Saubhagya S. Drug utilization pattern in Acne Vulgaris in Skin Outpatients department of a tertiary care teaching hospital at Dehradun, Uttarakhand. Int J Med Sci Public Heal. 2014;3(7):3-6.

Nibedita P, Jena M, Panda M, Dash M. A Study on the Prescribing Pattern of Drugs for Acne in a Tertiary Care Teaching Hospital in Odisha. J Clin Diagnostic Res. 2015;9(3):4-6.

Anuj KP, Subodh K, Manish K, Lalit M, Harihar D. Study of Drug Utilization Pattern for Skin Diseases in Dermatology OPD of an Indian Tertiary Care Hospital: A Prescription Survey. J Clin Diagnostic Res. 2016;10(2):1-5.

Gautam CS, Saha L, Fixed Dose Drug Combinations (FDC’s): rational or irrational: a view point, Br J Clin Pharmacol. 2007;65(5):795-6.

Gautam CS, Aditya S, Irrational drug combinations: Need to Sensitise undergraduates: Ind J Pharmacol. 2006;38:167-70.

Murray MD, Kroenke K. Polypharmacy and medication adherence: small steps on a long road. J Gen Intern Med. 2001;16:137-9.

Tripathi KD. Essential of Medical Pharmacology. 7th Ed. New Delhi; 2013:61-62.

Poudel A, Palaian S, Shankar PR, Jayasekara J, Izham MIM, Irrational Fixed dose combinations in Nepal: Need for intervention. Kathmandu University Medical Journal. 2008;6(3):399-405.

John K, Anatoli F. Management of acne. Can Med Assoc J. 2011;183(7):430-5.

National List of Essential Medicines. In 2015:1-117.




How to Cite

M., P., Holla, R., B. S., G., & A., P. (2017). A study of prescription pattern in the drug therapy of acne vulgaris at a tertiary care hospital in Mangalore, India. International Journal of Basic & Clinical Pharmacology, 7(1), 80–86. https://doi.org/10.18203/2319-2003.ijbcp20175679



Original Research Articles