Gabapentin a pre-emptive analgesic in post-operative pain: a randomised double blind placebo controlled study


  • Vikram Bhandari Department of Pharmacology, Shri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Geeta Sharma Department of Pharmacology, Shri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Dilip C. Dhasmana Department of Pharmacology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Meenakshi Gupta Department of Pharmacology, Shri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Jagdish P. Sharma Department of Anaesthsiology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Aditi Chaturvedi Department of Pharmacology, SSS Medical College, Dehradun, Uttarakhand, India



Cholecystectomy, Gabapentin, Postoperative pain


Background: Conventional analgesics, used in peri-operative period cause numerous adverse effects and are not free from interactions with co-administered drugs. Gabapentin has been shown to be effective in various types of neuropathic pain. The primary aim of this study was to evaluate gabapentin as a post-operative analgesic. The study also evaluates the analgesic requirement and safety of gabapentin in post-operative period.

Methods: Forty patients undergoing elective laparoscopic cholecystectomy were randomized to receive gabapentin or a matching placebo. The patients of group I received gabapentin 600mg orally 2 hrs before surgery and 12hrs after the first dose. The patients in group II received a matching placebo. Patients in both groups received diclofenac sodium 75mg i.m b.i.d for pain. Additional doses were given on demand and recorded.

Results: The present study found that gabapentin significantly reduced pain score and analgesic consumption as compared to a placebo for a period of 24 hours.

Conclusions: Gabapentin in the doses used was found to be effective in postoperative pain in patients undergoing planned laparoscopic cholecystectomy. It was found to be safe and no serious adverse events were reported.


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How to Cite

Bhandari, V., Sharma, G., Dhasmana, D. C., Gupta, M., Sharma, J. P., & Chaturvedi, A. (2017). Gabapentin a pre-emptive analgesic in post-operative pain: a randomised double blind placebo controlled study. International Journal of Basic & Clinical Pharmacology, 6(6), 1317–1322.



Original Research Articles