Changing trends of antibiotic resistance in neonatal sepsis in a tertiary care hospital
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20172037Keywords:
Antibiotic resistance, Neonatal sepsis, Retrospective study, Tertiary care hospitalAbstract
Background: Sepsis and other infections cause 15% neonatal deaths in India. The present study is to determine the resistance pattern of pathogens causing neonatal sepsis and to provide antibiogram to pediatricians for better patient management.
Methods: Positive Blood culture reports of neonatal sepsis cases detected during the years 2014 and 2015 were studied. The antibiotic resistance of the organisms found during the years 2014 and 2015 were compared by calculating the probability (p value) using the standard formula.
Results: Coagulase negative staphylococci (CONS) was the most common organism in 2014 whereas pseudomonas was predominant in 2015.Resistance of CONS to amoxycillin and ceftrioxone has significantly increased in 2015.Also resistance of CONS to vancomycin was noted. Resistance of Pseudomonas to cefuroxime, ceftazidime and amoxicillin/clavulanuic acid combination were increased but not significantly. There was also emerging resistance of pseudomonas to gentamicin and amikacin. Resistance of acinetobacter to cefuroxime, ceftrioxone and gentamicin has increased in 2015 but not significantly. Citrobacter showed a significant increase in resistance to amoxicillin/clavulanic acid combination (p=0.006).
Conclusions: Bacterial spectrum causing neonatal sepsis varies in different regions, varies in the same site during different time periods, also their antibiotic resistance pattern varies in different regions and changes constantly. Increase in resistance to commonly used antibiotics stress the need of rational use of antibiotics.
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References
Bhat SR. Achar’s textbook of Pediatrics. 4th Ed, University Press, Chapter 11, neonatology. 2099:215.
Neonatal and child health Profile, Department of maternal, newborn, child and adolescent health (MCA/WHO) Source: chreg/WHO, UNICEF) from Distribution of cases of neonatal and under 5 deaths (publlshed in Lancet 2014).
Parthasarathy A, Gupta P, Agarwal R, Menon PSN, Nair MKC, Sukumaran TV. IAP Textbook of Pediatrics. 5th Ed. JayPee Brothers; 2013:46.
Shah AJ, Mulla SA, Revdiwala SB. Neonatal sepsis: high antibiotic resistance of the bacterial pathogens in a neonatal intensive care unit of a tertiary care hospita. J Clin Neonatol. 2012;1(2):72-5.
Investigators of Delhi Neonatal study (DeNIS) collobaration. Characterisation and antimicrobial sensitivity of sepsis pathogens in neonates born in tertiary care centers in Delhi, India: a cohort study. The Lancet Global health. 2016;4(10):e752-e760.
Sharma CM, Agrawal RP, Sharan H, Kumar B, Sharma D, Bhatia SS. Neonatal Sepsis: Bacteria and their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit. J Clin Diagn Res. 2013 Nov;7(11):2511-3.
Marwah P, Chawla D, Chander J, Guglani V, Marwah A. Bacteriological profile of neonatal sepsis in a tertiary-care hospital of Northern India. Indian Pediatr. 2015;52(2):158-9.
Viswanathan R, Singh AK, Mukherjee S, Mukherjee R, Das P, Basu S. Aetiology and antimicrobial resistance of neonatal sepsis at a tertiary care centre in eastern India: a 3 year study. Indian J Pediatr. 2011Apr;78(4):409-12.
Al-Taiar-A, Hammoud MS, Cuiquing I, Lee JK, Lui KM, Nakwan N, Isaac D. Neonatal infections in China, Malaysia, Hong Kong and Thailand. Arch Dis Child Fetal Neonatal Ed. 2013May;98(3):F249-55.
Brunton LL, Chabner BA, Knollman BC. Goodman and Gilman’s Pharmacological basis of Therapeutics. 12th edition. 2011:1493,1496,1508.
Levinson W. Review of Medical Microbiology and Immunology, 13th ed. McGraw Hill education; 2014:214.
Stanton K, Behrman STGS. Nelson’s Text Book of Pediatrics. 19th ed, Elseviers (Saunders) Chapter 103.5, page 635, Chapter103.8, page 644.
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