Effect of add-on proton pump inhibitors on parameters of glycemic control in type-2 diabetic patients

Amruta P. Patil; Prashant A. Shirure

doi:10.18203/2319-2003.ijbcp20172219

Authors

Amruta P. Patil Department of Pharmacology, Dr. Vaishampayan Memorial Government Medical College, Solapur 413003, Maharashtra, India
Prashant A. Shirure Department of Pharmacology, Dr. Vaishampayan Memorial Government Medical College, Solapur 413003, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20172219

Keywords:

β cell neogenesis, Proton pump inhibitors, Raised gastrin level, Type 2 diabetes mellitus

Abstract

Proton pump inhibitors (PPIs) block the parietal cell H+/K+ ATPase, are superior at suppressing acid secretion & promoting peptic ulcer healing, wildly used clinically for the therapy of gastro-esophageal reflex disease, gastritis due to excess stomach acid, and gastric ulcers. After blocking the production of gastric acid, the proton-pump inhibitors indirectly elevate serum gastrin levels via a negative feedback effect. Evidences are reported that gastrin promotes β cell neogenesis in pancreatic ductal complex, modest pancreatic β cell replication and improvement of glucose tolerance in animal models. Some recent clinical studies have shown improved glucose tolerance in type-2 diabetes mellitus (T2DM). Although PPIs may be possible candidates for a new approach in the therapy of diabetes, a prospective, long-term, randomized, double-blind, placebo-controlled study is needed to establish the effect of PPIs on glycemic control in a large number of patients with T2DM.

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