DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20170940

An experimental evaluation of anti-inflammatory activities of some combined NSAID preparations in albino rats

Rajashekar Y. R., Shobha S. N.

Abstract


Background: Non-steroidal anti-inflammatory drugs are among the most commonly used drugs across the globe and they are also available over the counter for minor symptoms of pain and inflammation. Their toxicity profile limits their continued usage and search is continuing for the better effective and safer agent.

Methods: Interaction of paracetamol with diclofenac, ibuprofen and mefenamic acid were studied on carrageenan induced rat paw edema and cotton pellet induced granuloma models. Potentiation of these NSAIDs by paracetamol was also studied on same models.

Results: Addition of paracetamol did not increase anti-inflammatory activity of diclofenac, ibuprofen and mefenamic acid in both acute and subacute models of inflammation. Paracetamol found to potentiate the ibuprofen action in anti-inflammatory model where as in subacute inflammatory model diclofenac action was potentited.

Conclusions: Our study does not support the rationality of various fixed dose combination of NSAIDs with paracetamol available in market. Either NSAIDs to be used individually or their dose need to be decreased in fixed dose combination.


Keywords


Anti-inflammatory action, Diclofenac, Fixed dose combinations, Ibuprofen, Mefenamic acid, Paracetamol

Full Text:

PDF

References


Konturek SJ. Prevention of ethanol and aspirin and aspirin induced gastric mucosal leions by paracetamol and salicylates in rats: role of endogenous prostaglandins. Gut. 1972;23:536-40.

Von Kolfchoten AA. Protection by paracetamol against various gastric irritants in the rat. Toxicol. App Pharmacol. 1987;69:37-42.

Wong S, Gardocki JF. Anti-inflammatory and anti- arthtritic evaluation of acetaminophen and its potentiation of tolmetin. J Pharmacol. Exp Ther. 1983;226:626-32.

Steel RW. Oral antipyretic therapy: Evaluation of aspirin-acetaminophen combination. Amer J Child. 1972;123:204-07.

Breivik EK. Combining diclofenac with acetaminophen or acetaminophen-codine after oral surgery. Pharmacol. Ther. 1999;66:625-35.

Copper SA. The relative efficacy of ibuprofen in dental pain. Compend. Contin. Edu. Dent. 1988;7:578-88.

Hazra A. A comparative evaluation of ibuprofen and ibuprofen+paracetamol in post-episiotomy pain. Ind. J Clin. Practice. 1996;7:49-53.

Singh GP, Singla R. Comparative evaluation of ibuprofen and ibuprofen+paracetamol combination in osteoarthritis. In. Med. Gaz. 1997;131:236-42.

Ghosh MN. Fundamentals of experimental pharmacology, Calcutta: Scientific book agency. Calcutta. 1984;230:148-53.

Turner RA. Screening methods in pharmacology, New York and London, Academic Press Inc. 1965:322-23.

Vogel HG, Vogel WK. Drugs discovery and evaluation, Pharmaclogical Assays, Germany, Springer Publications. 1997:758-59.

Graham DY. Non steroidal anti-inflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa. Clin Pharmacol. Ther. 1985;38:65-70.