DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20170943

An experimental evaluation of gastro protective activity of paracetamol on ulcerogenicity of some NSAIDs in albino rats

Rajashekar Y. R., Shobha S. N.

Abstract


Background: Fixed dose combinations (FDCs) of NSAIDs are commonly prescribed and extensively sold over the counter. An indiscriminate usage of them leads to toxicity, mainly involving gastrointestinal system. Paracetamol appears to have controversial reputation regarding its gastro protective action. In this background, the study was planned to evaluate gastro protective effect of paracetamol on the ulcerogenicity of some relatively new NSAIDs in their therapeutic and sub therapeutic doses.

Methods: Gatric toxicity and gastric juice analysis- Pyloric ligation method was adopted for assessing the ulcer index of 3 NSAIDs namely aceclofenac, nimesulide and lornoxicam individually and in combination with paracetamol. Gastric juice collected was subjected for total juice volume, free acidity, combined acidity and total acid output.

Results: Paracetamol produced non significant gastric damage similar to that of control. When co administered with therapeutic doses of aceclofenac, nimesulide and lornoxicam, there was significant decrease in their gastric toxicity in a uniform manner and the ulcerogenicity of these NSAIDs in sub therapeutic doses was not affected by paracetamol. This upholds the uniform gastro protective activity of paracetamol in this study and this could be explained by its anti acid secretory action on gastric juice.

Conclusions: Paracetamol, itself has least gastric damaging property. When co administered with other NSAIDs, their toxicity is rather reduced than enhancing the mucosal damage by them. Thus FDCs of various NSAIDs available in market are partially justifiable.


Keywords


FDC, Gastroprotection, NSAIDs, Paracetamol, Ulcer index

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