DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20164757

A prospective observational study of prescription pattern of drugs used in the treatment of osteoarthritis in a tertiary care hospital

Lokesh V. Patil, Manisha Nara

Abstract


Background: Treatment of Osteoarthritis aims at reducing pain and improving mobility. NSAIDS are commonly prescribed for symptomatic relief despite well documented adverse effects. Paracetamol with its better safety profile is recommended as the initial analgesic of choice. Osteoarthritis has significant socio-economic impact on the patients and not many studies are available to reflect upon the prescription pattern of drugs in Osteoarthritis. Hence, this study was chosen to generate important feedback to the clinician. The objectives of the study were to study the prescribing pattern of drugs used in the treatment of Osteoarthritis in Tertiary care hospital.

Methods: Prescription for 300 osteoarthritis patients collected cross-sectional for 6 months from orthopedic out-patient department were analyzed.

Results: 60% of females were affected. Average age of study was 56.46+/- 7.4 years. Knee joint (87.33%) was most commonly affected joint. Average number of drugs prescribed was 2.62 +/- 0.76. Out of 786 drugs prescribed 45.8% were NSAIDs. Paracetamol was underutilized.

Conclusions: Paracetamol was underutilized while other NSAIDs were over prescribed.


Keywords


Acetaminophen, Osteoarthritis, Prescription pattern

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References


Mahajan A, Verma S, Tandon V. Osteoarthritis. JAPP. 2005;53:634-41.

David JH, Victoria LJ. The Epidemiology of Osteoarthritis; Best Practice and Research Clinical Rheumatology. 2014;28:5-15.

Lawrence RC, Felson DT, Helmick CG, Arnold. National Arthritis Data Workgroup: estimated of the prevalence of arthritis and other rheumatic conditions in the United States: part II, arthritis and rheumatism. 2008;58(1):26-35.

Woolf AD, Pfleger B. Burden of Major Musculoskeletal conditions bulletin of World Health Organization. 2003;81:646-56.

Brooks PM. Impact of Osteoarthritis on individuals and society: How much disability? Social consequences and health economic implications. Curr. Opin Rheumatol. 2002;14:573-7.

Ullal SD, Narendranath S. Prescribing pattern for osteoarthritis in a tertiary care hospital. Journal of clinical and diagnostic research. 2010;4:2421-6.

Jadhav MP, Dominic JC, Mukte AP. A Prospective Observational Study To Assess Quality Of Life And Prescription Pattern In Osteoarthritis Patients at a Tertiary Care Health Center in Mumbai, Indian J med sci. 2011;65(2):58-63.

Rowen TC, Dominic C, Charles BE. Estrogen alone and joint symptoms in the women’s health initiative randomized trial. NIH public access, menopause. 2013;1-16.

Kulkarni SK, Bishnoi M, Kumar A. Prescription Monitoring of Management Pattern of Osteoarthritis with Non-Steroidal Anti-Inflammatory Drugs at PUHC, Chandigarh in India. Indian Journal of pharmaceutical sciences. 2006;68(4):525-7.

Bhosale RR, Ramanad JP, Zende AM. Drug utilization pattern in outpatient department of government medical college and hospital. International Journal of Basic and Clinical Pharmacology. 2003;2(4):403-6.

Gupta M, Malhotra S. Pattern of prescription of non-steroidal antiinflammatory drugs in orthopedic out-patient clinic of a North Indian tertiary care hospital. Indian J pharm. 2005;37:404-5.

Abidi A, Gupta S, Kansal S. Prescription auditing and drug utilization pattern in a tertiary are teaching hospital of western UP. International Journal of basic and clinical pharmacology. 2012;1(3):184-90.

Hochberg MC. Morbidity in osteoarthritis. Clinical Exp Rheumatology J. 2008;26,5(51);S120-4.

Richard CM, Bars ML, Schimdely N, Dougados M. Paracetamol in osteoarthritis of the knee. Ann Rheum.Dis. 2004;63:923-30.