Published: 2017-04-24

Knowledge, attitude and practices of pharmacovigilance among the postgraduate and undergraduate medical students in a tertiary care hospital in Central India

Mohit Kulmi, Pooja Reddy, Shilpi Dhakre, Meghna Shinde, Chhaya Goyal


Background: Adverse Drug Reactions (ADRs) are one of the underestimated causes of morbidity and mortality. Monitoring of these ADRs is at the core of any pharmacovigilance program. ADR monitoring suffers from lack of reporting from health care personnels. Unless we know the current knowledge, attitude and practices of the budding doctors it’s difficult to design corrective measures to improve reporting. The present study was designed to assess the knowledge, attitude and practices of pharmacovigilance and ADR reporting among undergraduate and postgraduate medical students.

Methods: This was a questionnaire-based, observational study. The questionnaire had six questions each pertaining to knowledge, attitude and practices of pharmacovigilance and ADR reporting. Factors discouraging ADR reporting were also studied. Descriptive statistics were carried out and one-way ANOVA was applied to find the statistical difference between the groups.

Results: A total of 288 subjects were approached for the study of which 229 agreed to participate. It was observed that the knowledge of the participants regarding ADR reporting and pharmacovigilance was satisfactory. 68% of respondents felt that educational programmes have a positive effect on ADR reporting. 15% of respondents admitted of having reported an ADR. The mean scores of knowledge, attitude and practices of ADR reporting were considerably higher in postgraduates as compared to undergraduates (p-value <0.05).

Conclusions: The study concluded that participants of study were aware of the importance of ADR reporting but it did not reflect in their practices. There is a need to create awareness and to educate these future physicians about Pharmacovigilance.


ADR reporting, KAP, Pharmacovigilance, PvPI

Full Text:



The Importance of Pharmacovigilance - Safety Monitoring of Medicinal Products [Internet]. 2017 [cited 11 February 2017]. Available from:

Lee A, Thomas SHL. Adverse drug reactions. In: Walker R., Edward C., editors. Clinical Pharmacy and Therapeutics. 3rd ed. Churchill Livingstone; 2003:33-46.

Wu WK, Pantaleo N. Evaluation of outpatient adverse drug reactions leading to hospitalization. Am J Health Syst Pharm. 2003;60:253-9.

Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ. 2004;329:15-19.

Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279(15):1200-5.

UMC | Members [Internet]. 2017 [cited 11 February 2017]. Available from:

Rakesh RCP, Adepu R. Design and implementation of adverse drug reaction reporting system in community pharmacies. Indian J Pharm. 2009;2(2):32-7.

Rajesh R, Vidyasagar S, Muralidhar Varma D. An Educational Intervention to assess Knowledge Attitude Practice of pharmacovigilance among Health care professionals in an Indian tertiary care teaching hospital. Int J PharmTech. 2011;3(2):678-92.

Praveen S, Prakash RJ, Manjunath GN, Gautham MS, Kumar N. Adverse Drug Reaction reporting among medical and dental practitioners: a KAP study. Indian J Med Spec. 2013;4:10-5.

Vora MB, Paliwal NP, Doshi VG, Barvaliya MJ, Tripathi CB. Knowledge of adverse drug reactions and pharmacovigilance activity among the undergraduate students of Gujarat. Int J Pharm Sci Res. 2012;3:1511-5.

Sivanandy S, Arul Kumaran K, Rajasekaran A. Knowledge assessment in adverse drug reactions and reporting. Archives Pharm Prac. 2013;4(3):104.

Desai CK, Iyer G, Panchal J, Shah S, Dikshit RK. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting among prescribers at a tertiary care hospital. Perspect Clin Res. 2011;2:129-36.

Gupta P, Udupa A. Adverse drug reaction reporting and pharmacovigilance: Knowledge, attitudes and perceptions among the resident doctors. J Pharm Sci Res. 2011;3:1064-9.

Ramesh M, Parthasarathi G. Adverse drug reaction reporting: Attitudes and perceptions of medical practitioners. Asian J Pharm Clin Res. 2009;2:10-4.

Khan SA, Goyal C, Chandel N, Rafi M. Knowledge, attitude and practice of doctors to adverse drug reaction reporting in a teaching hospital in India: An observational study. J Nat Sci Biol Med. 2013;4:191-6.

Hardeep, Bajaj JK, Kumar R. A survey on the knowledge, attitude and the practice of pharmacovigilance among the health care professionals in a teaching hospital in northern India. J Clin Diagn Res. 2013;7:97-9.

Muraraiah S, Rajarathna K, Sreedhar D, Basavalingu D, Jayanthi CR. A questionnaire study to assess the knowledge, attitude and practice of Pharmacovigilance in a paediatric tertiary care centre. J Chem Pharm Res. 2011;3:416-22.

Pimpalkhute SA, Jaiswal KM, Sontakke SD, Bajait CS, Gaikwad A. Evaluation of awareness about pharmacovigilance and adverse drug reaction monitoring in resident doctors of a tertiary care teaching hospital. Indian J Med Sci. 2012;66:55-61.

Remesh A. Identifying the reasons for under reporting of ADR: A cross sectional survey. Res J Pharm Biol Chem Sci. 2012;3:1379-86.

Lee KK, Chan TY, Raymond K, Critchley JA. Pharmacists’ attitudes toward adverse drug reaction reporting in Hong Kong. Ann Pharmacother. 1994;28:1400-3.

Herdeiro MT, Figueiras A, Polonia J, Gestal-Otero JJ. Influence of pharmacists' attitudes on adverse drug reaction reporting: a case-control study in Portugal. Drug Saf. 2006;29:331-40.

Okezie EO, Olufunmilayo F. Adverse drug reactions reporting by physicians in Ibadan, Nigeria. Pharmacoepidemiol Drug Saf. 2008;17:517-22.

Chakrabarty M, Thawani V. Starting a pharmacovigilance centre: actions for implementation. J Pharmacol Pharmacother. 2011;2(4):295-9.