Protective effect of Phyllanthus fraternus against cyclophosphamide-induced nephrotoxicity in rats


  • Rakesh Singh Moirangthem Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Ngangom Gunindro Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Dipdeba Singh Takhellambam Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Sucheta Devi Khuraijam Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • N. Meena Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • S. Rita Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India



Cyclophosphamide, Nephrotoxicity, Nephroprotective, Phyllanthus fraternus


Background: Cyclophosphamide is commonly used against malignancies, such as leukemia and solid organ cancers. It can induce nephrotoxicity in cancer patients thereby complicating the initiation of chemotherapy. The study is to evaluate the effect of Phylllanthus fraternus against cyclophosphamide induced nephrotoxicity in albino rats.

Methods: In this study, a total of 20 albino rats were divided into four groups of five each. Group I (normal control) received i.p. injection of normal saline. While, group II, III and IV received single dose (200 mg/kg b/w) of cyclophosphamide i.p. on day 1. Group III and IV received 200 mg/kg and 400 mg/kg of aqueous extract of Phyllanthus fraternus respectively p.o. daily for 10 days. All the groups were fed with standard diet and water ad libitum. Serum levels of creatinine, urea and albumin were estimated. Histopathology of renal tissues was compared among the groups.

Results: The renal parameters significantly improved in groups III and IV after 10 days of treatment with the extract. The histopathology study also supported the finding.

Conclusions: The aqueous extract of Phyllanthus fraternus possesses protective effect against cyclophosphamide induced nephrotoxicity.


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How to Cite

Moirangthem, R. S., Gunindro, N., Takhellambam, D. S., Khuraijam, S. D., Meena, N., & Rita, S. (2017). Protective effect of Phyllanthus fraternus against cyclophosphamide-induced nephrotoxicity in rats. International Journal of Basic & Clinical Pharmacology, 6(4), 984–989.



Original Research Articles