Efficacy of vijaysar, aloevera alone and their combination in the treatment of newly diagnosed cases of type 2 diabetes mellitus: a randomized single blind prospective study

Authors

  • Arvind Kumar Maurya Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India
  • Atul Jain Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India
  • Asha Pathak Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India
  • Pankaj Chaudhary Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India
  • Neeraj Rajdan Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Saifai, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20171112

Keywords:

Aloevera, Diabetes mellitus, Vijaysar

Abstract

Background: Diabetes mellitus is a disease was known since ancient time and all system of medicine over world were tried to cure this disease. Unfortunately the numbers of diabetes patients are increasing day by day due to many risk factors such as sedentary life, obesity etc.

Methods: A total of 120 patients with newly diagnosed type 2 diabetes mellitus attending OPD of UPUMS, Saifai, Etawah, Uttar Pradesh, India, were included in the study. Patients were divided into 4 groups. Group-1, 2, 3 and 4 received Aloevera, Vijaysar, Aloevera + Vijaysar and Glimepiride respectively for thirteen weeks. Sample for fasting blood sugar and postprandial blood sugar were measured at baseline, 1st, 2nd, 3rd, 5th, 8th and at 13th week. HbA1c and Lipid profile were measured at baseline and at thirteen week.

Results: Significant decrease in FPG, 2hPG, and HbA1c level were achieved in all groups but effects was maximum in Glimepiride group. Vijaysar had shown better glucose control than Aloevera as well as Aloevera + Vijaysar group. Synergism was shown by both herbal drugs for FPG control but not for 2hPG. The Effect of Vijaysar alone on 2hPG was similar to Glimepiride.

Conclusions: Vijaysar could be a promising herbal drug for the treatment of mild uncomplicated cases of type-2 diabetes mellitus; however both drugs have shown synergism for FPG control. Both herbal drugs were safe during our study, only one patient of Vijaysar group had complaint of diarrhoea, which was subsided one week later.

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Published

2017-03-25

How to Cite

Maurya, A. K., Jain, A., Pathak, A., Chaudhary, P., & Rajdan, N. (2017). Efficacy of vijaysar, aloevera alone and their combination in the treatment of newly diagnosed cases of type 2 diabetes mellitus: a randomized single blind prospective study. International Journal of Basic & Clinical Pharmacology, 6(4), 962–967. https://doi.org/10.18203/2319-2003.ijbcp20171112

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Original Research Articles