Efficacy of vijaysar, aloevera alone and their combination in the treatment of newly diagnosed cases of type 2 diabetes mellitus: a randomized single blind prospective study

Arvind Kumar Maurya, Atul Jain, Asha Pathak, Pankaj Chaudhary, Neeraj Rajdan


Background: Diabetes mellitus is a disease was known since ancient time and all system of medicine over world were tried to cure this disease. Unfortunately the numbers of diabetes patients are increasing day by day due to many risk factors such as sedentary life, obesity etc.

Methods: A total of 120 patients with newly diagnosed type 2 diabetes mellitus attending OPD of UPUMS, Saifai, Etawah, Uttar Pradesh, India, were included in the study. Patients were divided into 4 groups. Group-1, 2, 3 and 4 received Aloevera, Vijaysar, Aloevera + Vijaysar and Glimepiride respectively for thirteen weeks. Sample for fasting blood sugar and postprandial blood sugar were measured at baseline, 1st, 2nd, 3rd, 5th, 8th and at 13th week. HbA1c and Lipid profile were measured at baseline and at thirteen week.

Results: Significant decrease in FPG, 2hPG, and HbA1c level were achieved in all groups but effects was maximum in Glimepiride group. Vijaysar had shown better glucose control than Aloevera as well as Aloevera + Vijaysar group. Synergism was shown by both herbal drugs for FPG control but not for 2hPG. The Effect of Vijaysar alone on 2hPG was similar to Glimepiride.

Conclusions: Vijaysar could be a promising herbal drug for the treatment of mild uncomplicated cases of type-2 diabetes mellitus; however both drugs have shown synergism for FPG control. Both herbal drugs were safe during our study, only one patient of Vijaysar group had complaint of diarrhoea, which was subsided one week later.


Aloevera, Diabetes mellitus, Vijaysar

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Karalliedde J, Gnudi L. Diabetes mellitus, a complex and heterogeneous disease and the role of insulin resistance as a determinant of diabetic kidney disease. Nephrol. Dial. Transplant. 2016;31(2):206-13.

Cavan D, Femandes JDR, Makaroff L, Ogurtsova K, Webber S. The IDF Diabetes Atlas. 7th edition. Switzerland: International Diabetes Federation. 2015;18-20.

Baily CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care. 1989;12:553-64.

Ayodhya S, Kusum S, Anjali S. Hypoglycaemic activity of different extracts of various herbal plants Singh. Int J Ayurveda Res Pharm. 2010;1(1):212-24.

ICMR study group. Efficacy of vijayasar (pterocarpus marsupium) in the treatment of newly diagnosed patients with type 2 diabetes mellitus: a flexible dose double-blind multicenter randomized controlled trial. Diabetologia croatica. 2005;34(1):13-20.

Agarwal. OP. Prevention of atheromatous heart disease. Angiology. 1985;485-92.

Ghannam N, Kingston M, Al-Meshaal IA, Tariq M, Parman NS, Woodhouse N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. Horm Res. 1986;24:288-94.

Ajabnoor MA. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J Ethnopharmacol. 1990;28:215-20.

Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine. 1996;3:245-8.

Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine. 1996;3:241-3.

Zarrintan A, Mobasseri M, Zarrintan A, Ostadrahimi A. Effects of Aloe Vera Supplements on Blood Glucose Level and Lipid Profile Markers in Type 2 Diabetic Patients: A Randomized Clinical Trial Pharmaceutical Sciences. 2015;21:65-71.

Pari L, Satheesh MA. Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin-and nicotinamide-induced diabetic rats. Life Sciences. 2006;79(7):641-5.

Anandharajan R, Pathmanathan K, Shankernarayanan NP, Vishwakarma RA, Balakrishnan A. Upregulation of GLUT-4 and PPARĪ³ by an isoflavone from Pterocarpus marsupium on L6 myotubes: A possible mechanism of action. Journal of Ethnopharmacology. 2005;97(2):253-60.

Mishra A, Srivastava R, Srivastava SP, Gautam S, Tamrakar AK, Maurya R, et al. Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb. And analysis of phytoconstituents. Indian Journal of Experimental Biology. 2013;51(5):363-74.

Manickam M, Ramanathan M, Farboodniay, Jahromi MA, Chansouria JPN, Ray AB. Antihyperglycemic Activity of Phenolics from Pterocarpus marsupium. J. Nat. Prod. 1997;60:609-10.

Maruthupandian A and. Mohan VR. Antidiabetic, Antihyperlipidaemic and Antioxidant activity of Pterocarpus marsupium Roxb. In alloxan induced diabetic rats. Int. J. Pharm Tech Res. 2011;3(3).

Dwivedi KN, Misra S. Experimental Evaluation of Hypoglycaemic Activity of a Compound Herbal Plant Formulation against Acute Hyperglycaemic Condition. International Journal of Scientific Research. 2013;2(9):17-9.

Grover JK, Vats V, Yadav S. Effects of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism. Molecular and Cellular Biochemistry. 2002;241(1-2):53-9.

Kedar P, Chakrabarti CH. Blood sugar, blood urea and serum lipid as influenced by Gurmar preparation, Pterocarpus marsupium, and Taramindus indica in diabetes mellitus. Marashtra Medical Journal. 1981;28:165.

Singh PK, Baxi D, Banerjee S, Ramachandran AV. Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model. Experimental and Toxicologic Pathology. 2012;64(5):441-8.

Yajnik VH, Acharya HK, Vithlani MP, Yajnik NV. Efficacy and safety of D-400, an herbal formulation, in diabetic patients. The Indian Practitioner. 1993;66(12):917-22.

Jahromi MF, Ray AB, Chansouria JPN. Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. Journal of Natural Products. 1993;56(7):989-94.

Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and Anti-hypercholesterolemic Effects of Aloe vera Leaf Gel in Hyperlipidemic Type 2 Diabetic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Planta Med. 2012;78(4):311-6.