Drugs used in postoperative care of bypass surgery- An overview

Mirza Shiraz Baig, Kishore Sonkusare, Prakashchandra Rambhau Gade


Postoperative care of cardiac surgical patients have shown important changes parallel to the surgical improvements in recent years. The post-operative approach to these patients is best directed by dividing their problems into the systems like cardiovascular care, Bleeding-Thrombosis and Transfusion Strategies, CNS care, Respiratory & renal care, Postoperative pain and sedation management and lastly managing complications if any. The present article explains the drugs as therapeutic agents used in management of post-operative bypass surgery.


Drugs, Postoperative, CABG

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Konuralp C, Idiz M. Systematic approach on postoperative care of the cardiac surgical patients. Anadolu Kardiyol Derg 2003;3:156-61.

Shanmugam G. Vasoplegic syndrome--The role of methylene blue. Eur J Cardiothorac Surg 2005;28:705-10.

Faber P, Ronald A, Millar BW. Methylthioninium chloride: pharmacology and clinical applications with special emphasis on nitric oxide mediated vasodilatory shock during cardiopulmonary bypass. Anaesthesia 2005;60:575-87.

Grose R, Strain J, Greenberg M, et al. Systemic and coronary effects of intravenous milrinone and dobutamine in congestive heart failure. J Am Coll Cardiol 1986;7:1107-13.

Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med 2001;135:1061-73.

Martin KB, Klinger JR, Rounds SI. Pulmonary arterial hypertension: New insights and new hope. Respirology 2006;11:6-17.

Puskas JD, Williams WH, Duke PG, et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: A prospective, randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003;125:797-808.

Gerrah R, Snir E, Brill A, et al. Platelet function changes as monitored by cone and platelet analyzer during beating heart surgery. Heart Surg Forum 2004;7:E191-5.

Frangos SG, Chen AH, Sumpio B. Vascular drugs in the new millennium. J Am Coll Surg 2000;191:76-92.

Ferraris VA, Ferraris SP, Joseph O, et al. Aspirin and postoperative bleeding after coronary artery bypass grafting. Ann Surg 2002;235:820-7.

Ferraris VA, Ferraris SP, Lough FC, et al. Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting. Ann Thorac Surg 1988;45:71-4.

Silvestry SC, Smith PK. Current status of cardiac surgery in the abciximab-treated patient. Ann Thorac Surg 2000;70(2 Suppl):S12-9.

Cattaneo M, Harris AS, Stromberg U, et al. The effect of desmopressin on reducing blood loss in cardiac surgery: a meta-analysis of double-blind, placebo-controlled trials. Thromb Haemost 1995;74:1064-70.

Baggish AL, Sabatine MS. Clopidogrel use in coronary artery disease. Expert Rev Cardiovasc Ther 2006;4:7-15.

Kolff WJ, Effler DB, Groves LK, et al. Pulmonary complications of open-heart operations: Their pathogenesis and avoidance. Cleve Clin Q 1958;25:65-83.

Fagon JY, Chastre J, Domart Y, et al. Nosocomial pneumonia in patients receiving continuous mechanical ventilation: Prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis 1989;139:877-84.

Fischer UM, Weissenberger WK, Warters RD, et al. Impact of cardiopulmonary bypass management on postcardiac surgery renal function. Perfusion 2002;17:401-6.

Hall R, Adderley N, MacLaren C, et al. Does intrathecal morphine alter the stress response following coronary artery bypass grafting surgery? Can J Anesth 2000;47:463-6.

Hynninen MS, Cheng DC, Hossain I, et al. Nonsteroidal anti-inflammatory drugs in treatment of postoperative pain after cardiac surgery. Can J Anesth 2000;47:1182-7.

Montes FR, Sanchez SI, Girlado JC, et al. The lack of benefit of tracheal extubation in the operating room after coronary artery bypass surgery. Anesth Analg 2000;91:776-80.

Cross JT Jr, Campbell GD Jr. Therapy of nosocomial pneumonia. Med Clin North Am 2001;85:1583-94.

Carney DE, Meguid MM. Current concepts in nutritional assessment. Arch Surg 2002;137:42-5.

Kendler BS. Supplemental conditionally essential nutrients in cardiovascular disease therapy. J Cardiovasc Nurs 2006;21:9-16.

Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA 2001;286:944-53.

Alexander JW. Nutritional pharmacology in surgical patients. Am J Surg 2002;183:349-52.