Mirabegron: first β3 agonist in treatment of overactive bladder

Authors

  • Paramdeep Singh Gill Department of Pharmacology, Sri Guru Ram Das Institute of Medical sciences and Research, Amritsar, India
  • Nipunjot Grewal Department of Pharmacology, Sri Guru Ram Das Institute of Medical sciences and Research, Amritsar, India

Keywords:

Overactive bladder, Anticholinergics, β3 agonist

Abstract

Mirabegron is the first and only β3 agonist approved by US FDA in June 2012 for treatment of Overactive bladder with symptoms of urge incontinence, urgency and urinary frequency. It is the first oral OAB treatment with a distinct mechanism of action since the launch of anticholinergic agents 30 years ago. It causes relaxation of detrusor smooth muscle by its agonist action at β3 receptors leading to increased storage capacity of bladder. It has been studied extensively in more than 10,000 individuals over 10 years.

References

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Lapitan MC, Chye PL. The epidemiology of overactive bladder among females in Asia: a questionnaire survey. Int Urogynecol J Pelvic Floor Dysfunct 2001;12:226-31.

Fantl JA, Wyman JF, McClish DK, et al. Efficacy of bladder training in older women with urinary incontinence. JAMA 1991;265:609-13.

Herbison P, Hay-Smith J, Ellis G, Moore K. Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review. BMJ 2003;326:841-4.

Thomas AW, Abrams P. Lower urinary tract symptoms, benign prostatic obstruction and the overactive bladder. BJU Int 2000;85 Suppl 3:57-68.

Myrbetriq (Mirabegron) prescribing information. Available at http://www.us.astellas.com/docs/myrbetriq-full-pi.pdf. Accessed 19 September 2012.

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Published

2017-02-04

How to Cite

Gill, P. S., & Grewal, N. (2017). Mirabegron: first β3 agonist in treatment of overactive bladder. International Journal of Basic & Clinical Pharmacology, 1(2), 120–121. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1410

Issue

Section

New Drug Update