Fatal Stevens-Johnson syndrome induced by phenytoin: a case report
Keywords:
TENS (Toxic Epidermal Necrolysis Syndrome), Phenytoin, Stevens-Johnson syndrome (SJS), Lyell syndromeAbstract
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare (one to two per 10,00,00 population per year) but life threatening adverse drug reactions. Drugs commonly implicated are anti-epileptics, anti-microbials and non-steroidal anti-inflammatory drugs (NSAIDS). Amongst anti-epileptics, carbamazepine and phenytoin are the major culprits. We report here a fatal case of SJS due to phenytoin.
Metrics
References
Doshi MS, Patel P, Shah SP, Dikshit RK. Intensive monitoring of adverse drug reactions in hospitalized patients of two medical units at a tertiary care teaching hospital. J Pharmacol Pharmacother 2012;3:308-13.
Thomas H, French E. Toxic epidermal necrolysis and Stevens-Johnson Syndrome. Orphanet J of Rare Dis 2010;5:39.
Maja Mockenhaupt. The current understanding of Stevens–Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 2011;7(6):803-15.
Patel TK, Barvaliya MJ, Sharma D, Tripathi C. A systematic review of the drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population. Indian J Dermatol Venereol Leprol 2013;79:389-9.
Devi K, George S, Criton S, Suja V, Sridevi PK. Carbamazepine-the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: a study of 7 years. Indian J Dermatol Venereol Leprol 2005;71(5):325-8.
Patel PP, Gandhi AM, Desia CK, Desia MK. An analysis of drug induced Stevens-Johnson syndrome. Indian J Med Res 2012;136:1051-3.
Lobao B, Martins C, Sousa M, Marques S, Pedroso E. Phenytoin-induced Lyell's syndrome. BMJ case rep 2012;70:121-2.
Schmidt D, Kluge W. Fatal toxic epidermal necrolysis following reexposure to phenytoin: a case report. Epilepsia 1983,24(4):440-3.
Patel TK, Barvaliya MJ, Sharma D, Tripathi C. A systematic review of the drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population. Indian J Dermatol Venereol Leprol 2013;79:389-98.
Chave TA, Mortimer NJ, Sladden MJ. Toxic epidermal necrolysis: current evidence, practical management and future directions. Br J Dermatol 2005; 153: 241-53.
Bilimoria FE, Shah BJ. Drug reactions. In: Valia AR, Valia RG, eds. IADVL Textbook of Dermatology. 3rd ed. Mumbai: Bhalani Publishing House;2013:1645-6.
