Trimethoprim-sulfamethoxazole induced toxic epidermal necrolysis: a case report

Authors

  • Rama R. Bhosale Department of Pharmacology, Govt. Medical College, Kolhapur, District- Kolhapur, Maharashtra, India
  • Pradeep S. Bodke Department of Psychiatry, Govt. Medical College, Latur, District- Latur, Maharashtra, India
  • Abhishek V. Patil Department of Skin and VD, Govt. Medical College, Kolhapur, Dist- Kolhapur, Maharashtra, India
  • Shivaji H. Bhurke Department of Medicine, B. J. Govt. Medical College, Pune, District- Pune, Maharashtra, India

Keywords:

Sulfamethoxazole, Trimethoprim, Toxic epidermal necrolysis

Abstract

Toxic epidermal necrolysis (TEN) is a rare but serious dermatological disorder commonly caused as an idiosyncratic reaction to drugs and the most common drugs implicated are antibiotics, anticonvulsants and non-steroidal anti-inflammatory drugs. Here, we report a case of trimethoprim-sulfamethoxazole induced TEN in a 26 years old female.

References

KD Tripathi. Essentials of Medical Pharmacology, Jaypee publication, 6th edition 2008; 686.

Harr T, French LE. Toxic epidermal necrolysis and Stevens-Johnson syndrome. Orphanet J Rare Dis 2010; 5:39.

Brett AS, Philips D, Lynn AW. Intravenous immunoglobulin therapy for Steven-Johnson syndrome. South Med J 2001; 94: 342-3.

Amit Bhasin, Anil Gurtoo, Latika Gupta, Gunjan Aggarwal. First case of mirtazepine-induced Stevens-Johnson syndrome from India. Indian J Pharmacol 2012;44:656-8.

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45.

Downloads

Published

2017-02-02

How to Cite

Bhosale, R. R., Bodke, P. S., Patil, A. V., & Bhurke, S. H. (2017). Trimethoprim-sulfamethoxazole induced toxic epidermal necrolysis: a case report. International Journal of Basic & Clinical Pharmacology, 2(6), 841–842. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1381