Prescription pattern of drugs in pregnancy induced hypertension in a tertiary care hospital

Naveen Kumar T, Tadvi NA, Kaul R

Abstract


Background: The objective of this study was to evaluate the prescription pattern of drugs in pregnancy induced hypertension in a tertiary care hospital.

Methods:A retrospective observational study was conducted by department of Pharmacology in collaboration with the Department of Obstetrics in Kamineni Institute of Medical Sciences, Narketpally after taking permission from the Institutional Review Board. WHO basic indicators were indicators were used for studying the prescribing pattern of drugs.

Results: Out of the total prescriptions studied the most commonly prescribed antihypertensive was Methyldopa, followed by Nifedipine. Amlodipine, Atenolol and Magnesium sulphate were the other drugs prescribed. Majority drugs prescribed were from category B and C. Single drug therapy was prescribed in 46.94% patients. The use of fixed dose combinations was low.

Conclusion: The incidence of single drugs therapy and two drugs was high. Irrational prescriptions were few. The present pattern of prescriptions can be improved by advocating rational drug prescription and awareness regarding safe use of drugs to the obstetricians.


Keywords


Antihypertensives, Drug use indicators, Pregnancy induced hypertension, Drug utilization studies

Full Text:

PDF

References


Roberts J, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertens 2003;41(3):437-45.

Folic M, Folic N, Varjacic M, Jakovljevic M, Jankovic S. Antihypertensive drug therapy for hypertensive disorders in pregnancy. Acta Medica Medianae.2008;47(3):67-71.

Saudan P, Brown MA, Buddle ML et al. Does gestational hypertension become pre-eclampsia. British Journal of Obstetrics and Gynaecology,1998,105(11):1177-84

Lankoande J, Ouedraogo A, Ouedraogo CM. Gynecology-obstetrics at the Yalgado- Ouedraogo National Hospital Center. Eclampsia: epidemiologic, clinical and prognostic aspects Sante, 1997;7(4):231-5.

Conde Agudelo A, Beliza JM. Risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women. BJOG 2000;107(1):75-83.

Tiwari H, Kumar A, Kulkarni SK. Prescription monitoring of antihypertensive drug utilization at the Punjab university health centre in India. Singapore Med J 2004;45(3):117.

WHO Expert Committee. The selection of Essential Drugs, Technical Report Series no.615. Geneva:World Health Organization,1977.

Gupta N, Sharma D, Garg SK, Bhargava VK. Auditing of prescriptions to study utilization of antimicrobials in tertiary hospital. Indian J Pharmacol,1997;29(6):411-5

Pai PG, Shenoy J, Sanji N. Prescribing Patterns of antihypertensives drugs in a south Indian tertiary care hospital. Drug Invention Today 2011;3(4):38-40.

Venkateshwaramurthy N, John Christy, Perumal P. Study on antihypertensives in pre-eclampsia. Asian Journal of Pharmaceutical and Clinical Research 201;5(3):126-8.

Sachdeva PD, Patel BG. Drug utilization studies-Scope and future perspectives. International Journal on Pharmaceutical and Biological Research 2010;1(1):11-6.

Drug facts & Comparison 2005, FDA Pregnancy categories A-4.

Sharma R, Kapoor B, Verma U. drug utilization pattern during pregnancy in North India. Indian J Med Sci. 2006;60(7):277-86.

Tanuja VH, Santosh Kumar J, Manjunath S, Vinod Kumar CS. Drug utilization study of antihypertensives in obstetric practice in a tertiary care hospital. IJACPT. 2010;1(3):1006-10.