Prescription pattern of antimicrobial agents in a teaching hospital of South India

Ajay M. Khade, M Shakeel M Bashir, Savya George, Sheethal Annaldesh, Kishor A. Bansod

Abstract


Background: Use of irrational and unnecessary antimicrobials remains common in the developing countries. The present study was conducted to evaluate the use of antimicrobial agents in the tribal district hospital of Andhra Pradesh India.

Methods: In this retrospective study, 200 hospitalized cases from medicine, surgery, obstetrics and gynaecology and paediatrics departments were randomly selected.

Results: Most common diagnosis was febrile illness (15%) followed by gastroenteritis (10%) and malaria (8%). Antimicrobials were used in 57% cases. All the cases were managed by empirical treatment. Cefixime (40%) was the most common antimicrobial followed by ampicillin (32.50%), metronidazole (30%) and ciprofloxacin (26.50%). Use of antimicrobial monotherapy (41.67%) and 2 drug therapy (36.46%) was common.

Conclusion: Empirical use of higher antimicrobial agents is routine and cheap antimicrobials like ampicillin are still most useful drugs in the region. There is a need of specific essential drug list for the region.


Keywords


Antimicrobials, Drug resistance, Irrational medication

Full Text:

PDF

References


Patel V, Vaidya R, Naik D, Borker P. Irrational drug use in India: A prescription survey from Goa. J Postgrad Med 2005;51(1):9-12.

Award AI, Himad HA. Drug use practices in the teaching hospitals of Khartoum State, Sudan. Eur J Clin Pharmacol 2006;62:1087-93.

Mohanty BK, Aswini M, et al. Prescription Pattern in Rajahmundry, India. Journal of Clinical and Diagnostic Research 2010 Feb;(4):2047-51.

Belongia EA, Schwartz B. Strategies for promoting judicious use of antibiotics by doctors and patients. Br Med J 1998;317:668-71.

Guglielmo BJ. Antimicrobial therapy. Cost-benefit considerations. Drugs 1989; 38: 473-80.

Ganguly NK, Arora NK, Chandy SJ, Fairoze MN, Gill JPS, Gupta U, Hossain S, et al. Rationalizing antibiotic use to limit antibiotic resistance in India. Global Antibiotic Resistance Partnership (GARP) - India Working Group. Indian J Med Res September 2011; 134: 281-94.

Lunde PK, Baksaas I. Epidemiology of drug utilization basic concepts and methodology. Acta Med Scand Suppl 1988; 721: 7-11.

Hogerzeil HV. Promoting rational prescribing: An international perspective. Br J Clin Pharmacol 1995; 39:1-6.

Laporte JR, Porta M, Capella D. Drug utilization studies: A tool for determining the effectiveness of drug use. Br J Clin Pharmacol 1983;16:301-4.

National informatics centre Adilabad, Official website of Adilabad collectorate.mht, {accessed on September 20, 2011}. Available from: http://www.adilabad.ap.gov.in.

Marr JJ, Moffet HL, Kunin CM. Guidelines for improving the use of antimicrobial agents in hospitals: A statement by the Infectious Diseases Society of America. J Infect Dis 1988;157:869-76.

Al Shimemeri A, Al Ghadeer H, Memish Z. Antibiotic utilization pattern in a general medical ward of a tertiary medical center in Saudi Arabia. Avicenna Journal of Medicine 2011;1(1):8-11.

Giri BR, Pant HP, Ravi Shankar P, Sreeramareddy CT, Sen PK. Surgical site infection and Antibiotics use pattern in a tertiary care hospital in Nepal. J Pak Med Assoc March 2008;58(3):148-151.

Thomas M, Govil S, Moss BV, Joseph A. Monitoring of antibiotic use in a primary and a tertiary care hospital. Journal of Clinical Epidemiology February 1996;49(2):251-4.

Khan FA, Sheikh N, Salman MT. Patterns of prescription of antimicrobial agents in the department of otorhinolaryngology in a tertiary care teaching hospital. Int Res J Pharm Pharmacol August 2011;1(5):79-85. Available from: http://www.interesjournals.org/IRJPP.

Vaccheri A, Silvani MC, Bersaglia L, Motola D, Strahinja P, Vargiu A, et al. A 3 year survey on the use of antibacterial agents in five Italian hospitals. J Antimicrob Chemother 2008;61(4):953-8.