A comparative study of dexmedetomidine vs midazolam for sedation and hemodynamic changes during tympanoplasty and modified radical mastoidectomy


  • Dhara A. Vyas Department of Anaesthesia, C. U. Shah Medical College, Surendranagar-363001, India
  • Nikunj H. Hihoriya Department of Pharmacology, GCS Medical College, Hospital and Research Centre, Ahmedabad-380025, India
  • Rina A. Gadhavi Department of Anaesthesia, C. U. Shah Medical College, Surendranagar-363001, India


Dexmedetomidine, Midazolam, ENT surgeries


Background: The benzodiazepine, Midazolam, has been used medication given for sedation in tympanoplasty and mastoidectomy because of a number of beneficial effects. However, Dexmedetomidine is a highly selective α2-adrenoceptor agonist is emerging as preferred choice now a day. The aim of the study is to compare hemodynamic stability and sedation under Dexmedetomidine vs Midazolam during tympanoplasty and modified radical mastoidectomy done under local anaesthesia.

Methods: After obtaining ethics clearance from institution and written informed consent from patients, 50 patients of age group 15 to 50 years of ASA grade i & ii were selected and divided in to two groups:

Group D: Inj. Dexmedetomidine 1µg/kg over 15min, followed by 0.5µg/kg/hr (n= 25).

Group M: Inj. Midazolam 0.05 mg/kg i.v. slowly, followed by 0.01mg/kg/hr (n= 25).

Arterial blood pressure, heart rate and sedation level were monitored. The surgeons and patients were asked to rate their satisfaction, using the Likert scale.

Results: Sedation score difference between group Dand group M was not statistically significant. There was no statistically significant difference found in diastolic blood pressure of both the groups. There was a significant reduction in heart rate in group D as compared to  group M. Surgeon’s satisfaction score and patient’s satisfaction score both were high in group D compare to group M.

Conclusions: For monitored anaesthesia care in ENT surgeries performed under local anaesthesia, inj. Dexmedetomidine could be a better alternative over inj. Midazolam.


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How to Cite

Vyas, D. A., Hihoriya, N. H., & Gadhavi, R. A. (2017). A comparative study of dexmedetomidine vs midazolam for sedation and hemodynamic changes during tympanoplasty and modified radical mastoidectomy. International Journal of Basic & Clinical Pharmacology, 2(5), 562–566. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1320



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