Selected neurobehavioural evaluation of Leucas Aspera in wistar albino rats


  • Kavitha R. Department of Pharmacology, Sri Muthukumaran Medical College & Research Institute, Chennai, Tamil Nadu, India
  • Kannan R. Senior Drug Safety Associate, ICON Clinical Research, Chennai, Tamil Nadu, India
  • Glory Josephine I. Associate Professor, Sri Balaji Medical College & Hospital, Chennai, Tamil Nadu, India


Leucas aspera, Neurobehavioural effects, Nutraceutical property


Background: Leucas Aspera is used in traditional medicine for many ailments. The present study was designed to evaluate the neuro behavioural effects in Wistar albino rats after oral administration of leaves of Leucas Aspera for 28 days.

Methods: Wistar albino rats of either sex were treated with the aqueous suspension of dried powdered leaves of L. aspera. Three different groups of animals received L. aspera suspension in doses of 50 mg/kg/day, 100 mg /kg/day or 200mg/kg/day orally for 28 days. The animals were weighed once in a week and the food and water consumption was monitored every day. Behavioural changes in these animals were monitored every week using Rotarod, Actophotometer and William’s maze.

Results: A significant increase in body weight, food and water consumption in rats could be recorded after 3rdand 4th week of treatment with 200mg/kg/dayL.aspera. However, there were no changes in any of the behavioural responses in L .aspera treated groups compared to control.

Conclusions: The unaltered neuro behavioural responses after L. aspera treatment indicate the safe nature of this medicinal plant. The significant increase in food consumption and body weight changes suggest a potential anabolic/ nutraceutical property of L. aspera.


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How to Cite

R., K., R., K., & I., G. J. (2017). Selected neurobehavioural evaluation of Leucas Aspera in wistar albino rats. International Journal of Basic & Clinical Pharmacology, 2(4), 433–437. Retrieved from



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