Comparative study of the effect of atorvastatin and garlic extract in experimentally induced hypercholesterolemia in rabbits

Authors

  • Indrani Dalal Department of Pharmacology, Midnapore Medical College, Kolkata, India
  • Mohua Sengupta Department of Pharmacology, Medical College, Kolkata, India
  • Suhrita Paul Department of Pharmacology, Medical College, Kolkata, India
  • A. N. Mishra Department of Pharmacology, MGM Medical College, Jamshedpur, India

Keywords:

Hypercholesterolemia, Garlic, Atorvastatin

Abstract

Background: The abundant resource of drugs and its beneficial properties are hidden in our natural and Indigenous sources, which are under constant evaluation by man. Cholesterol lowering ability of ethanol extract of garlic was evaluated in comparison to atorvastatin, the most frequently used lipid lowering agent in rabbits.

Methods: Hypercholesterolemia was induced to the animals with cholesterol powder (50mg/kg) for the study duration (16 weeks). At the end of 4 weeks, they were randomly selected and divided into 3 groups (n=6). Group II received Cholesterol + atorvastatin 10 mg daily; Group III received Cholesterol + 0.1g garlic extract kg b. w. daily while Group I continued with cholesterol powder (to serve as control) for the rest study period. Serum cholesterol, LDL, HDL and Triglycerides were estimated using the enzymatic method at 0, 4, 8, 12, 16 weeks in all the groups. The results were tabulated and analyzed statistically using one way ANOVA test.

Results: The results indicate that both atorvastatin and garlic extract have a definite role in retarding the rate of weight gain as a consequence to high cholesterol diet in rabbits. Also, there is fewer rises in all the lipid parameters in both the treatment groups when compared to the control group.

Conclusion: Though atorvastatin is definitely more effective in reducing the lipid parameters but it also significantly lowers HDL where as Garlic shows promising results when compared to placebo and also has a favourable effect on HDL. Garlic can be recommended as a dietary supplement for long term use without toxic effects for its wide range of medicinal properties in general and therapeutic potential inpatients with CAD in particular.

Metrics

Metrics Loading ...

References

Brodia A, Arora SK, Rathore BS, Bhu N. Essential oil of garlic on blood lipids and fibrinolytic activity in patients of coronary artery disease. J Assoc Physicians India 1978;26:327-31.

Prevention of coronary heart disease. Report of a WHO Expert Committee. WHO, Geneva. Tech. Rep. Ser.1982;678.

Gordon T, Castelli WP, Hijorland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary artery disease. The Framingham Study. Am J Med. 1977;62:707-14.

Kastelein JJP. The realities of dyslipidaemia: what do the studies tell us? Eur Heart J Suppl. 2005;7:F27-33.

Anitschkow N, Chatalaw O’ Ober. Experimentalle Cholesterinsteatose undihre Boden tungfur die entstenung einger. Pathologist Cher Prozessess Centrabe, All Path. Anat 1913;24:1.

Hunninghake DB and Probstfield JL Drug Treatment of hyperlipoproteinemia. In Hyperlipidemia: Diagnosis and therapy (Rifkind BM, And Levy RI.eds) Grunne and Stratton, Inc New York 1977; 327-62.

National Cholesterol Education Program. Executive Summary of third report of the National Cholesterol Education program expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA 2001;285(19):2486-97.

Scandinavian Simvastatin Survival Study. Randomized controlled Trial of Cholesterol lowering 4444 patients with Coronary Heart Disease: The 4S Study. Lancet 1994;344:1383-9.

Omar MA, Wilson JP, Cox TS. Rhabdomyolysis and HMG CoA-Reductase inhibitor. Ann. Pharmacother 2001;35:1096-107.

Warren CPW. Some aspects of medicine in the greek bronze age. J Med Hist 1970;14:364-77.

Hindjo, Pilar Herrero and France MC. Biol Soc Espan Hist Farm 1968;19(73).

Srivastava KC, Bordia A, Verma SK. Garlic (Allium sativum) for disease prevention. South African J Science 1995;91:68-77.

Barness J, Anderson LA, Phillipson JD, eds. Garlic. In: Herbal medicines. 2nd ed. London: Pharmaceutical Press 2002;226-40.

Bordia A. Effect of garlic on blood lipids in patients with coronary heart disease. Am J Clin Nutr 1981;34:2100-3.

Ali M, Thromson M. Consumption of a garlic clove a day could be beneficial in preventing thrombosis. Prostaglandins. Leukot Essent Fatty Acids 1995;53:211-12.

Bordia A, Verma SK. Effect of garlic feeding on regression of experimental atherosclerosis in rabbits. Artery 1980;7:428-37.

Brodia A, Arora SK, Kothari LK, Jain KC, Rathore BS, Rathore AS, Dube MK, Bhu N. The protective action of essential oil of garlic in cholesterol fed rabbits. Atherosclerosis 1975;22:103-9.

Sainani GS, Pesai DB. Indian J Med Res 1979;7:776-80.

Koch HP, Lawson LD. Garlic: the science and therapeutic application of Allium sativum L. And related species. 2nd ed. Baltimore: Williams & Wilkins, 1996.

Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med 1993;119(7):599-605.

Silagy C, Neil A. Garlic as a lipid lowering agent -a Meta analysis. J.R. Coll Physicians Lond 1994;28:39-45.

Ackerman RT, Murlow CD, Ramirez G, Gardner CD, Morbidoni L, Lawrence VA. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med 2001;161:813-24.

Carrol KK. Plasma cholesterol and liver cholesterol biosynthesis in rabbits fed commercial or semi-synthetic diets with or without added fat or oils. Atherosclerosis 1971;13:67-76.

Downloads

Published

2017-01-31

How to Cite

Dalal, I., Sengupta, M., Paul, S., & Mishra, A. N. (2017). Comparative study of the effect of atorvastatin and garlic extract in experimentally induced hypercholesterolemia in rabbits. International Journal of Basic & Clinical Pharmacology, 2(4), 397–402. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1288

Issue

Section

Original Research Articles