Drugs in pregnancy and lactation

Ashfaque K. Shaikh, Madhuri D. Kulkarni

Abstract


Drug use during pregnancy and lactation is an almost inevitable event. Some of the drugs may have adverse effects on the baby on exposure. It is therefore necessary for the physician to be aware of the changes in pharmacokinetics and pharmacodynamics during pregnancy. Knowledge about the known teratogens and drugs safe to be used during pregnancy is essential on the part of the prescribing physician. There are many factors affecting drug passage into the milk and thus affecting the child in some cases. There are also some drugs affecting lactation. All this data needs to be carefully studied by the physician.


Keywords


Pharmacokinetics, Pharmacodynamics, Pregnancy, Teratogen, Lactation

Full Text:

PDF

References


Satoskar RS, Bhandarkar SD, Rege NN. Drugs, pregnancy and the infant. In: Satoskar RS, Bhandarkar SD, Rege NN, editors. Pharmacology and pharmacotherapeutics. 21st ed. Mumbai, India: Popular Prakashan Pvt. Ltd; 2009. p. 1094-104.

Koren G. Special aspects of perinatal & pediatric pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and clinical pharmacology. 11th ed. New Delhi. Tata McGraw Hill; 2009. p. 1025-36.

Hodgson E. A Textbook of Modern Toxicology. 4th edition. John Wiley and Sons: New Jersey; 2010. p:268.

Mittal S, Seth V. Drugs in pregnancy and lactation. In: Seth SD, Seth V, editors. Textbook of pharmacology. 3rd ed. New Delhi: Elsevier; 2009. p. XV.3-12.

van Gelder MM, van Rooij IA, Miller RK, Zielhuis GA, de Jong-van den Berg LT, Roeleveld N. Teratogenic mechanisms of medical drugs. Hum Reprod Update 2010;16:378-94.

Tripathi KD. Adverse drug effects. In: Tripathi KD, editor. Essentials of medical pharmacology. 6th ed. New Delhi: Jaypee Brothers; 2008. p. 85.

Davis DB. Drugs in pregnancy--the issues for 2010. J Popul Ther Clin Pharmacol 2010;17(3):e332-5.

Mittal S, Gupta MM. Drugs used in pregnancy. In: Kohli K, Gupta M, Tejwani S, editors. Contemporary perspectives on clinical pharmacotherapeutics. 1st ed. New Delhi: Elsevier; 2006. p. 744-54.

Meyer JM. Pharmacotherapy of Psychosis and Mania. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s The pharmacological basis of therapeutics. 12th ed. New York: Mc Graw Hill; 2011. p. 417-55.

Della-Guistina K. Special considerations for drugs used during breastfeeding. In: Kohli K, Gupta M, Tejwani S, editors. Contemporary perspectives on clinical pharmacotherapeutics. 1st ed. New Delhi: Elsevier; 2006. p. 755-66.