Possible toxic effect of antihypertensive drug olmesartan on male reproductive system of rat

Srinivasa Jayachandra, AnnGie Ng


Background: To evaluate the possible toxic effect of a new angiotensin II receptor antagonist or blocker, olmesartan medoxomil, on the male reproductive system of rat.

Methods: Twelve Sprague Dawley rats, randomly divided into two groups: treated group (n=6) and control group (n=6). Olmesartan medoxomil (5mg/kg/dose) was fed to the treated group once daily for 28 days. Sperm motility, count and morphology and pituitary gonadal hormonal levels were assessed.

Results: Despite some fluctuations in sperm count, sperm motility, and concentration of testosterone, FSH and LH levels of treated group when compared to controls, the results were statistically insignificant.

Conclusions: It is therefore concluded that olmesartan medoxomil did not adversely affect the male reproductive health of treated rats.


Olmesartan, Sperm count, Testosterone

Full Text:



Manimunda SP, Sugunan AP, Benegal V, Balakrishna N, Rao MV, Pesala KS.. Association of hypertension with risk factors & hypertension related behaviour among the aboriginal Nicobarese tribe living in Car Nicobar Island, India. Indian J Med Res 2011;133:287-93.

Contrera F, de la Parte MA, Cabrera J, Ospino N, Israili ZH, Velasco M. Role of angiotensin II AT1 receptor blockers in the treatment of arterial hypertension. Am J Ther 2003;10:401-8.

Schiffrin EL. Vascular and cardiac benefits of angiotensin receptor blockers. Am J Med 2002;11:409-18.

Whittaker A. A review of olmesartan medoxomil - a new angiotensin II receptor blocker. Br J Cardiol 2005;12:125-9.

Redon J, Fabia MJ. Efficacy in angiotensin receptor blockade: a comparative review of data with olmesartan. J Renin Angiotensin Aldosterone Syst 2009;10:147-56.

Nangaku M, Miyata T, Sada T, Mizuno M, Inagi R, Ueda Y, et al. Anti-hypertensive agents inhibit in vivo the formation of advanced glycation end products and improve renal damage in type 2 diabetic nephropathy rat model. J Am Soc Nephrol 2003;14:1212-22.

Wehling M. Can the pharmacokinetic characteristics of olmesartan medoxomil contribute to the improvement of blood pressure control? Clin Ther 2004;26:21-7.

Shetty AJ, Narayana K, Bairy KL, Bhat P, D'Souza U. The effect of carbamazepine on sperm counts in Wistar rats--reflecting upon its mitogenic potential. Reprod Biol 2007;7:177-81.

D'Souza UJ. Effect of tamoxifen on spermatogenesis and tubular morphology in rats. Asian J Androl 2004;6:223-6.

Amann RP. Evaluating testis function non-invasively: how epidemiologist-andrologist teams might better approach this task. Hum Reprod 2010;25:22-8.

Metwally SA, Hekma AA, Fawzy HM, Hamdy A. The Protective Effect of Linseed Oil Against Carbendazim Induced Testicular Toxicity in Rats. Eur J Sci Res 2011;49:208-24.

Carreira JT, Mingoti GZ, Rodrigues LH, Silva C, Perri SH, Koivisto MB. Impact of proximal cytoplasmic droplets on quality traits and in-vitro embryo production efficiency of cryopreserved bull spermatozoa. Acta Vet Scand 2012;54:1-7.

Leung PS, Sernia C. The renin-angiotensin system and male reproduction: new functions for old hormones. J Mol Endocrinol 2003;30:263-70.

Forgari R, Preti P, Derosa G, Marasi G, Zoppi A, Rinaldi A, Mugellini A. Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men. Eur J Clin Pharmacol 2002;58:177-80.

Martin-du Pan R. Endocrine pathology: Effects on male fertility, 2003. Available at http://www.gfmer.ch/Books/Reproductive_health/Endocrine_ pathology.html. Accessed 27 August 2011.