Evaluation of Abelmoschus moschatus seed extract in psychiatric and neurological disorders


  • Haja Sherief Sheik Department of Pharmacology, Nandha College of Pharmacy, Koorapalayam Pirivu, Perundurai Main Road, Erode, Tamil Nadu, India
  • Niraimathi Vedhaiyan Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
  • Sengottuvelu Singaravel Department of Pharmacology, Nandha College of Pharmacy, Koorapalayam Pirivu, Perundurai Main Road, Erode, Tamil Nadu, India


Anti-depressant, Abelmoschus moschatus, Muscle relaxant, Rotarod, Pentylenetetrazole


Background: Abelmoschus moschatus is an aromatic and medicinal plant, used as traditional medicine in the Thirunelveli district and distributed in many parts of Asia, including India. The present study was aimed to evaluate central nervous system (CNS) activities of ethanolic seed extract of A. moschatus (AEAM).

Methods: Oral administration of AEAM at doses of 200 and 400 mg/kg on various behavioral models forced swim, tail suspension, light-dark box, hole-board, elevated-plus-maze, locomotor, strychnine, maximal electroshock induced seizure, pentylenetetrazole (PTZ), rotarod, climbing an inclined screen models were utilized.

Results: In the open field test, AEAM (200 and 400 mg/kg) increased the numbers of rearing. However, the number of central motor and ambulation were reduced. The number of entries and the time spent in the open arm were increased, whereas the number of locomotion was decreased (p<0.001) in elevated-plus-maze and actophotometer test, respectively. AEAM (200 and 400 mg/kg) protected the mice against the PTZ and strychnine-induced convulsions; it causes significant dose-dependent increase in latency of convulsion. Treatment with AEAM reduced the duration of the tonic hind limb extension, increased the hypnotics time and decreased motor co-ordination of experimental animals.

Conclusion: This study concludes A. moschatus is an alternative source for CNS drug development.


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How to Cite

Sheik, H. S., Vedhaiyan, N., & Singaravel, S. (2017). Evaluation of Abelmoschus moschatus seed extract in psychiatric and neurological disorders. International Journal of Basic & Clinical Pharmacology, 3(5), 845–853. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1115



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