DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20170325

Antibiotic trends in acute febrile illness

Riyaz Ahmed Siddiqui, Tanaji R. Shende, Y. Dhoble, Archana S. Borkar

Abstract


Background: Acute febrile illness has various etiologies. Different antimicrobials are used for different causes of fever to treat and there are interpersonal variations in prescription of antimicrobials. Therefore this study aims at to analyze the trends in the antimicrobial prescription in patients of acute febrile illness due to various etiologies in the medicine department of a tertiary care hospital.

Methods: It is a record based observational study that was carried out at NKP salve institute of medical sciences and RC, Nagpur. 200 case record files of patients admitted with a diagnosis of acute febrile illness in the dept. of Medicine due to various etiologies were analyzed. Antibiotics prescribed for various causes of acute febrile illness like respiratory tract infections, urinary tract infection, gastrointestinal infection, malarial infections, septicemia, meningitis, pyrexia of unknown origin etc. were noted and data was analyzed for prescription pattern of antimicrobials.

Results: Out of 200 patients of febrile illness the common clinical conditions for which antibiotics were prescribed were respiratory tract infections (upper respiratory tract infection 25.5% and lower respiratory tract infection 14%), acute gastroenteritis (20%), and urinary tract infection (13.5%) followed by, pyrexia of unknown origin (8.5%), viral fever (8%), malaria (7%), hepatitis A (1.5%), meningitis (1%) and rickettsial infection (1%). The commonly prescribed antibiotics were ceftriaxone in (19.37%) and cefixime (15.93%) followed by coamoxiclav (12.5%), azithromycin (11.87%), doxycycline (10.31%), ofloxacin and ornidazole (8.43%), levofloxacin (6.25%), ofloxacin (4.68%), ciprofloxacin (1.87%), artesunate (3.75%), artemether and lumefantrine (4.37%) and valacyclovir (0.625%).

Conclusions: Our study concluded that most common disease for which antibiotics prescribed were respiratory tract infection and gasterointestinal infections. Most common antibiotic used were third generation cephalosporins especially ceftriaxone and cefixime.


Keywords


Anti microbial agents, Gastrointestinal infections, Respiratory tract infection

Full Text:

PDF

References


Rani RA, Sundararajan T, Rajesh S, Jeyamurugan T. A Study on Common Etiologies of Acute Febrile Illness Detectable by Microbiological Tests in a Tertiary Care Hospital. Int. J. Curr. Microbiol. App. Sci. 2016;5(7):670-4.

Das D, Das B, Roy AD, Singh TSK. Common Infectious Etiologies of Acute Febrile Illness in a Remote Geographical Location: Could Scrub Typhus be the Most Common Cause? British Journal of Medicine and Medical Research. 2015;10(10):1-10.

Kashinkunti MD, Gundikeri SK, Dhananjaya M. Acute undifferentiated febrile illness- clinical spectrum and outcome from a ertiary care teaching hospital of north Karnataka. Int J Biol Med Res. 2013;4(2):3399-402.

Khety Z, Mohanta GP, Patvardhan S, Jain S. Studies on Antimicrobial Consumption in a Tertiary Care Private Hospital, India. IJPPR. 2016;6(1).

Reddy SN, Manohar B, Bhavani DM, Kejiya G, Sreevidya C, Ranganayakulu D. Prescribing pattern of drugs in pediatric wards at tertiary care teaching hospital. International Journal of Pharmacy Review and Research. 2015;5(4):374-8.

Venkateswaramurthy N, Murali R, Kumar RS. The study of drug utilization pattern in pediatric patients. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;5(3).

Narayan DS, Mangesh MM. A Study of Prescription Pattern of Antibiotics in Paediatric In-Patients at a tertiary care hospital in central India IJPR. 2016;6(8).

Meher BR, Mukharjee D, Udayshankar. A study on antibiotic utilization pattern in a general medicine ward of a tertiary care teaching hospital. Journal of Chemical and Pharmaceutical Research. 2014;6(7):1847-9.

Ahmad A, Revanker M, Haque I, Pravina A, Ivan R, Dasari R, et al. Study the Prescription Pattern of Antibiotics in the Medicine Department in a Teaching Hospital: A Descriptive Study. International Journal of Toxicological and Pharmacological Research. 2014;6(2):43-6.

Chitra B. Study on utilization pattern of antibiotics at a private corporate hospital. Indian Journal of Drugs. 2016;4(3):69-74.

Saleh N, Awada S, Awwad R, Jibai S, Arfoul C, Zaiter L, et al. evaluation of antibiotic prescription in the lebanese community: a pilot study. Infection ecology and epidemiology; 2015;5.

Kanish R, Gupta K, Juneja S, Bains HS, Kaushal S. Prescribing pattern and pharmacoeconomics of antibiotic use in the department of pediatrics of a tertiary care medical college hospital in northern India. Annals of tropical medicine and public health. 2015;8(4):101-4.

Chandy SJ, Thomas K, Mathai E, Antonisamy B, Kathleen A. Holloway 6 and Cecilia Stals by Lundborg Patterns of antibiotic use in the community and challenges of antibiotic surveillance in a lower-middle-income country setting: A repeated cross-sectional study in Vellore, south India. J. Antimicrob. Chemother. 2013;68(1):229-36.

Pasha SZ, Prasad BD, Shalem L, Chand TB, Veeramani G. Prescribing pattern and use of antibiotics and combination of antibiotics in a tertiary care teaching hospital. IAJPR. 2014;4(7):3172-81.

Bansal D, Mangla S, Undela K, Gudala K, D’Cruz S, Sachdev A, et al. Measurement of Adult Antimicrobial Drug Use in Tertiary Care Hospital Using Defined Daily Dose and Days of Therapy. Indian J Pharm Sci. 2014;76(3):211-7.