Gabapentin pre-treatment for pressor response to direct laryngoscopy and tracheal intubation: a randomized, double-blind, placebo-controlled study

Authors

  • Vikram Bhandari Department of Pharmacology, Himalayan Institute of Medical Sciences Dehradun, Uttarakhand, India Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and research, Amritsar, Punjab
  • Dilip C. Dhasmana Department of Pharmacology, Himalayan Institute of Medical Sciences Dehradun, Uttarakhand, India
  • Sheveta Dureja Department of Physiology, Chintpurni Medical College, Pathankot, Punjab, India
  • Jagdish P. Sharma Department of Anaesthesia, Himalayan Institute of Medical Sciences Dehradun, Uttarakhand, India
  • Praveendra K. Sachan Department of Surgery, Himalayan Institute of Medical Science, Dehradun, Uttarakhand, India
  • Aditi Chaturvedi Department of Pharmacology, Himalayan Institute of Medical Sciences Dehradun, Uttarakhand, India

Keywords:

Gabapentin, The pressor response, Laryngoscopy, Endotracheal intubation, Hemodynamic

Abstract

Background: Laryngoscopy and endotracheal intubation are associated with an increase in blood pressure (BP) and heart rate (HR). The present study was conducted to evaluate the role of gabapentin in attenuation of these hemodynamic changes.

Methods: Forty patients undergoing elective laparoscopic cholecystectomy under general anesthesia with standardized premedication and anesthetics were randomized to receive gabapentin or a matching placebo. The patients of Group I received gabapentin 600 mg orally 2 hrs before surgery and patients in Group II received a matching placebo. Patient’s HR, systolic BP (SBP), diastolic BP (DBP), mean BP (MBP), were monitored before and after 1, 2, 5, and 10 mins of endotracheal intubation.

Results: Comparison of SBP, DBP, and MBP at 1, 2, 5 and 10 mins after endotracheal intubation showed statistically significant attenuation in the gabapentin group when compared to placebo. Changes in the HR were not significant.

Conclusion: Gabapentin 600 mg, given 2 hrs before induction is effective in attenuating the pressor response to laryngoscopy and tracheal intubation.

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Published

2017-01-27

How to Cite

Bhandari, V., Dhasmana, D. C., Dureja, S., Sharma, J. P., Sachan, P. K., & Chaturvedi, A. (2017). Gabapentin pre-treatment for pressor response to direct laryngoscopy and tracheal intubation: a randomized, double-blind, placebo-controlled study. International Journal of Basic & Clinical Pharmacology, 3(5), 800–803. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1096

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Original Research Articles