Dapagliflozin: a new adjunct in the treatment of Type 2 diabetes mellitus

Authors

  • Mamta Sachdeva University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study (UGC-CAS) in Pharmaceutical Sciences, Panjab University, Chandigarh, India
  • Sameer Dhingra School of Pharmacy, Faculty of Medical Sciences, Eric Williams Medical Sciences Complex, Mount Hope, The University of the West Indies, St. Augustine, Trinidad and Tobago.
  • Milind Parle Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

Keywords:

Type 2 diabetes mellitus, Sodium-glucose cotransporter 2 inhibitor, Dapagliflozin

Abstract

Diabetes mellitus (DM) Type 2 is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. The classic symptoms are excess thirst, frequent urination, and constant hunger. Management of Type 2 diabetes focuses on lifestyle interventions, lowering other cardiovascular risk factors, and maintaining blood glucose levels in the normal range. There are several classes of anti-diabetic medications available and these include sulfonylureas, nonsulfonylurea secretagogues, alpha glucosidase inhibitors, thiazolidinediones, glucagon-like peptide-1 analog, and dipeptidyl peptidase-4 inhibitors. Recently, dapagliflozin (Farxiga™), a sodium-glucose cotransporter 2 inhibitor has been approved by Food and Drug Administration as an adjunct to diet and exercises to improve glycemic control in adults with Type 2 DM.

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Published

2017-01-25

How to Cite

Sachdeva, M., Dhingra, S., & Parle, M. (2017). Dapagliflozin: a new adjunct in the treatment of Type 2 diabetes mellitus. International Journal of Basic & Clinical Pharmacology, 3(4), 741–747. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1067

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Section

New Drug Update