Gabapentin for post-operative nausea and vomiting: a pilot study


  • Vikram Bhandari Department of Pharmacology,HIMS, Dehradun, Uttarakhand, India Department of Pharmacology SGRDIMSR, Amritsar, Punjab, India
  • Dilip C. Dhasmana Department of Pharmacology,HIMS, Dehradun, Uttarakhand, India
  • Jagdish P. Sharma Department of Anaesthesia,HIMS, Dehradun, Uttarakhand, India
  • Praveendra K. Sachan Department of Surgery, HIMS, Dehradun, Uttarakhand, India
  • Aditi Chaturvedi Department of Pharmacology,HIMS, Dehradun, Uttarakhand, India
  • Sheveta Dureja Department of Physiology, Chintpurni Medical College, Pathankot, Punjab, India


Gabapentin, Post-operative nausea and vomiting, Cholecystectomy


Background: Gabapentin has been used in perioperative setting for the management of post-operative pain for surgery performed under general anaesthesia. Post-operative nausea and vomiting (PONV) even with the use of newer agents remains a major problem. The primary aim of this study was to see if gabapentin use decreased PONV.

Methods: A total of 40 patients undergoing elective laparoscopic cholecystectomy under general anesthesia with standardized premedication and anesthetics were randomized to receive gabapentin or a matching placebo. The patients in Group I received gabapentin 600 mg orally 2 hrs before surgery and 12 hrs after the first dose. The patients in Group II received a matching placebo orally 2 hrs before surgery and 12hrs after the first dose. Patients in both groups received diclofenac sodium 75 mg i.m b.i.d for pain and ondensetron 4 mg i.v for PONV. Additional doses were given on demand and recorded. The treatment was double blinded.

Results: The present study did not find significant reduction in PONV score and antiemetic consumption in gabapentin group when compared to a placebo for a period of 24 hrs.

Conclusions: Gabapentin in the doses used was found to ineffective in post-operative nausea and vomiting in patients undergoing planned laparoscopic cholecystectomy with standardized pre-anaesthetic and anaesthetic medication.


Mann CV, Russell RCG, Williams NF. Introduction to surgery-Basic surgical principles. In: Bailey & Love Short Practice of Surgery. London: Chapman & Hall; 1995: 1.

Dolin SJ, Cashman JN. Tolerability of acute postoperative pain management: nausea, vomiting, sedation, pruritus, and urinary retention. Evidence from published data. Br J Anaesth. 2005;95(5):584-91.

Islam S, Jain PN. Post-operative nausea and vomiting (PONV): a review article. Indian J Anaesth. 2004;48(4):253-8.

Kapur PA. The big “little problem”. Anesth Analg. 1991;73(3):243-5.

Guyton AC, Hall JE. Physiology of gastrointestinal disorders. In: textbook of Physiology. 11th Edition. Philadelphia: Elsevier; 2006: 819.

Beal JE, Olson R, Laubenstein L, Morales JO, Bellman P, Yangco B, et al. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. J Pain Symptom Manage. 1995;10(2):89-97.

Hamann W, di Vadi PP. Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors. Lancet. 1999;353(9152):560.

Navari RM, Reinhardt RR, Gralla RJ, Kris MG, Hesketh PJ, Khojasteh A, et al. Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group. N Engl J Med. 1999;340(3):190-5.

Lee PJ, Pandit SK, Green CR. Postanesthetic side effects in the outpatient: which are the most important? Anesth Analg. 1995;79: 271.

García-Miguel FJ, Serrano-Aguilar PG, López-Bastida J. Preoperative assessment. Lancet. 2003;362(9397):1749-57.

Guttuso T Jr, Roscoe J, Griggs J. Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. Lancet. 2003;361(9370):1703-5.

Pandey CK, Priye S, Ambesh SP, Singh S, Singh U, Singh PK. Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study. J Postgrad Med. 2006;52(2):97-100.

Rorarius MG, Mennander S, Suominen P, Rintala S, Puura A, Pirhonen R, et al. Gabapentin for the prevention of postoperative pain after vaginal hysterectomy. Pain. 2004;110(1-2):175-81.

Al-Mujadi H, A-Refai AR, Katzarov MG, Dehrab NA, Batra YK, Al-Qattan AR. Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Can J Anaesth. 2006;53(3):268-73.

Turan A, Memiş D, Karamanlioğlu B, Yağiz R, Pamukçu Z, Yavuz E. The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery. Anesth Analg. 2004;99(2):375-8.

Werner MU, Søholm L, Rotbøll-Nielsen P, Kehlet H. Does an acute pain service improve postoperative outcome? Anesth Analg. 2002;95(5):1361-72.

Ture H, Takil A, Eti Z, Gogus FY. The effect of nitrous oxide on post-operative nausea and vomiting. Marmara Med J. 2007;20(2):85-91.

Ho KY. Gabapentin for postoperative nausea and vomiting prophylaxis. J Postgrad Med. 2006;52(3):230.

Pandey CK, Priye S, Singh S, Singh U, Singh RB, Singh PK. Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can J Anaesth. 2004;51(4):358-63.

Turan A, Karamanlioglu B, Memis D, Usar P, Pamukçu Z, Türe M. The analgesic effects of gabapentin after total abdominal hysterectomy. Anesth Analg. 2004;98(5):1370-3.




How to Cite

Bhandari, V., Dhasmana, D. C., Sharma, J. P., Sachan, P. K., Chaturvedi, A., & Dureja, S. (2017). Gabapentin for post-operative nausea and vomiting: a pilot study. International Journal of Basic & Clinical Pharmacology, 3(4), 627–631. Retrieved from



Original Research Articles